Long-term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes.

Autor: Ashby-Thompson M; New York Nutrition Obesity Research Center, Columbia University, New York, New York, USA.; Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA., Heshka S; New York Nutrition Obesity Research Center, Columbia University, New York, New York, USA., Anderson A; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Pownall H; The Methodist Hospital Research Institute, Houston, Texas, USA., Laferrère B; New York Nutrition Obesity Research Center, Columbia University, New York, New York, USA.; Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Balasubramanyam A; Department of Medicine, Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, Texas, USA., Heymsfield SB; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Wadden TA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Gallagher D; New York Nutrition Obesity Research Center, Columbia University, New York, New York, USA.; Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.; Institute of Human Nutrition, Columbia University, New York, New York, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 Jun; Vol. 32 (6), pp. 1093-1101. Date of Electronic Publication: 2024 May 13.
DOI: 10.1002/oby.24025
Abstrakt: Objective: The objective of the study was to test whether there are sustained effects of the Look AHEAD intensive lifestyle intervention (ILI), versus diabetes support and education (DSE), on weight and body composition 12 to 16 years after randomization.
Methods: Participants were a subset of enrollees in the Look AHEAD dual-energy x-ray absorptiometry substudy who completed the final visit, composed of men (DSE = 99; ILI = 94) and women (DSE = 134; ILI = 135) with type 2 diabetes and mean (SD) age 57.2 (6.4) years and BMI 34.9 (5.1) kg/m 2 at randomization. Dual-energy x-ray absorptiometry measured total and regional fat and lean masses at randomization, at Years 1, 4, and 8, and at the final visit. Linear mixed-effects regressions were applied with adjustment for group, clinic, sex, age, race/ethnicity, and baseline body composition.
Results: Weight and most body compartments were reduced by 2% to 8% (and BMI 4%) in ILI versus DSE in men but not women. ILI-induced loss of lean tissue did not show a lower percent lean mass versus DSE at 16 years after randomization.
Conclusion: ILI-related changes in weight, fat, and lean mass were detectable 12 to 16 years after randomization in men but, for unknown reasons, not in women. There was no evidence that the intervention led to a disproportionate loss of lean mass by the end of the study.
(© 2024 The Obesity Society.)
Databáze: MEDLINE
Externí odkaz: