Biomaterials science and surface engineering strategies for dental peri-implantitis management.

Autor: Yu YM; Department of Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, China.; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China., Lu YP; Department of Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, China.; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China., Zhang T; School of Materials Science and Engineering, Peking University, Beijing, 100871, China., Zheng YF; School of Materials Science and Engineering, Peking University, Beijing, 100871, China. yfzheng@pku.edu.cn., Liu YS; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China. liuyunsong@hsc.pku.edu.cn.; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China. liuyunsong@hsc.pku.edu.cn., Xia DD; Department of Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, China. dandanxia@pku.edu.cn.; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China. dandanxia@pku.edu.cn.
Jazyk: angličtina
Zdroj: Military Medical Research [Mil Med Res] 2024 May 13; Vol. 11 (1), pp. 29. Date of Electronic Publication: 2024 May 13.
DOI: 10.1186/s40779-024-00532-9
Abstrakt: Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant failure. Dental implants for clinical use barely have antibacterial properties, and bacterial colonization and biofilm formation on the dental implants are major causes of peri-implantitis. Treatment strategies such as mechanical debridement and antibiotic therapy have been used to remove dental plaque. However, it is particularly important to prevent the occurrence of peri-implantitis rather than treatment. Therefore, the current research spot has focused on improving the antibacterial properties of dental implants, such as the construction of specific micro-nano surface texture, the introduction of diverse functional coatings, or the application of materials with intrinsic antibacterial properties. The aforementioned antibacterial surfaces can be incorporated with bioactive molecules, metallic nanoparticles, or other functional components to further enhance the osteogenic properties and accelerate the healing process. In this review, we summarize the recent developments in biomaterial science and the modification strategies applied to dental implants to inhibit biofilm formation and facilitate bone-implant integration. Furthermore, we summarized the obstacles existing in the process of laboratory research to reach the clinic products, and propose corresponding directions for future developments and research perspectives, so that to provide insights into the rational design and construction of dental implants with the aim to balance antibacterial efficacy, biological safety, and osteogenic property.
(© 2024. The Author(s).)
Databáze: MEDLINE
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