History of Rectal Product Use and Country of Residence Influence Preference for Rectal Microbicide Dosage Forms Among Young Sexual and Gender Minorities: A Multi-country Trial Comparing Placebo Douche, Suppository, and Insert Products.

Autor: Giguere R; Division of Gender, Sexuality and Health, HIV Center for Clinical and Behavioral Research, New York State Psychiatric Institute and Columbia University, New York, NY, USA. rebecca.giguere@med.fsu.edu.; Center for Translational Behavioral Science, College of Medicine, Florida State University, Tallahassee, FL, USA. rebecca.giguere@med.fsu.edu., Balán IC; Center for Translational Behavioral Science, College of Medicine, Florida State University, Tallahassee, FL, USA., Kutner BA; Division of Gender, Sexuality and Health, HIV Center for Clinical and Behavioral Research, New York State Psychiatric Institute and Columbia University, New York, NY, USA.; Psychiatry Research Institute at Montefiore Einstein (PRIME), Albert Einstein College of Medicine, Bronx, NY, USA., Choi SK; University of Pennsylvania, Philadelphia, PA, USA., Tingler R; University of Pennsylvania, Philadelphia, PA, USA., Johnson S; FHI 360, Durham, NC, USA., Macagna N; FHI 360, Durham, NC, USA., Webster J; University of Pennsylvania, Philadelphia, PA, USA., Liu A; Bridge HIV at the San Francisco Department of Public Health, San Francisco, CA, USA., Chariyalertsak S; Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand., Hoesley C; University of Alabama at Birmingham, Birmingham, AL, USA., Gonzales P; IMPACTA Asociación Civil, Impacta Salud y Educación, San Miguel CES, Lima, Peru., Ho K; University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Kayange N; Blanytre CRS, Johns Hopkins University Research Project, Blantyre, Malawi., Palanee-Phillips T; Wits RHI, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Brown E; Statistical Center for HIV/AIDS Research & Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Zemanek J; Statistical Center for HIV/AIDS Research & Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Jacobson CE; FHI 360, Durham, NC, USA., Doncel GF; CONRAD, Eastern Virginia Medical School, Norfolk, VA, USA., Piper J; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Bauermeister JA; University of Pennsylvania, Philadelphia, PA, USA.
Jazyk: angličtina
Zdroj: AIDS and behavior [AIDS Behav] 2024 Aug; Vol. 28 (8), pp. 2577-2589. Date of Electronic Publication: 2024 May 13.
DOI: 10.1007/s10461-024-04360-9
Abstrakt: The DESIRE Study (MTN-035) explored product preference among three placebo rectal microbicide (RM) formulations, a rectal douche (RD), a suppository, and an insert, among 210 sexually active transgender people and men who have sex with men in five counties: the United States, Peru, Thailand, South Africa, and Malawi. Participants used each product prior to receptive anal sex (RAS) for 1 month, following a randomly assigned sequence, then selected their preferred product via computer assisted self-interview. In-depth interviews examined reasons for preference. We compared product preference and prior product use by country to explore whether geographic location and experience with the similar products impacted preference. A majority in the United States (56%) and Peru (58%) and nearly half in South Africa (48%) preferred the douche. Most in Malawi (59%) preferred the suppository, while half in Thailand (50%) and nearly half in South Africa (47%) preferred the insert. Participants who preferred the douche described it as quick and easy, already routinized, and serving a dual purpose of cleansing and protecting. Those who preferred the insert found it small, portable, discreet, with quick dissolution. Those who preferred the suppository found the size and shape acceptable and liked the added lubrication it provided. Experience with product use varied by country. Participants with RD experience were significantly more likely to prefer the douche (p = 0.03). Diversifying availability of multiple RM dosage forms can increase uptake and improve HIV prevention efforts globally.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: