Quality-adjusted life years for HER2-positive, early-stage breast cancer using trastuzumab-containing regimens in the context of cost-effectiveness studies: a systematic review.

Autor:	Khoirunnisa SM; Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Research Institute Science in Healthy Aging and healthcaRE, Groningen, the Netherlands.; Department of Pharmacy, Institut Teknologi Sumatera, Lampung Selatan, Indonesia., Suryanegara FDA; Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Research Institute Science in Healthy Aging and healthcaRE, Groningen, the Netherlands.; Department of Pharmacy, Universitas Islam Indonesia, Yogyakarta, Indonesia., Setiawan D; Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Banyumas, Indonesia.; Center for Health Economic Studies, Universitas Muhammadiyah Purwokerto, Banyumas, Indonesia., Postma MJ; Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Research Institute Science in Healthy Aging and healthcaRE, Groningen, the Netherlands.; Department of Economics, Econometrics and Finance, University of Groningen, Groningen, the Netherlands.; Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Centre of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.
Jazyk:	angličtina
Zdroj:	Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2024 Jun; Vol. 24 (5), pp. 613-629. Date of Electronic Publication: 2024 May 20.
DOI:	10.1080/14737167.2024.2352006
Abstrakt:	Introduction: This study aims to provide a comprehensive assessment of economic and health-related quality of life (HRQoL) outcomes for human epidermal growth factor receptor 2 (HER2)-positive, early-stage breast cancer patients treated with trastuzumab-containing regimens, by focusing on both Incremental Cost-Effectiveness Ratios (ICERs) and quality-adjusted life years (QALYs). Methods: A systematic search was conducted across PubMed, Embase, and Scopus databases without language or publication year restrictions. Two independent reviewers screened eligible studies, extracted data, and assessed methodology and reporting quality using the Drummond checklist and Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022), respectively. Costs were converted to US dollars (US$) for 2023 for cross-study comparison. Results: Twenty-two articles, primarily from high-income countries (HICs), were included, with ICERs ranging from US$13,176/QALY to US$254,510/QALY, falling within country-specific cost-effectiveness thresholds. A notable association was observed between higher QALYs and lower ICERs, indicating a favorable cost-effectiveness and health outcome relationship. EQ-5D was the most utilized instrument for assessing health state utility values, with diverse targeted populations. Conclusions: Studies reporting higher QALYs tend to have lower ICERs, indicating a positive relationship between cost-effectiveness and health outcomes. However, challenges such as methodological heterogeneity and transparency in utility valuation persist, underscoring the need for standardized guidelines and collaborative efforts among stakeholders. Registration: PROSPERO ID: CRD42021259826.
Databáze:	MEDLINE
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