A chronic intermittent haemodialysis pig model for functional evaluation of dialysis membranes.

Autor:	Yamamoto S; Division of Companion Animal Surgery, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido Prefecture, Japan.; Department of Hemo-Vascular Advanced Medicine, Cardiorenal Reseach Laboratory, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Umeno H; Medical Technology and Material Laboratory, Asahi Kasei Medical Co. Ltd., Fuji, Shizuoka, Japan., Sano Y; Medical Technology and Material Laboratory, Asahi Kasei Medical Co. Ltd., Fuji, Shizuoka, Japan., Koremoto M; Product Development Strategy Department, Asahi Kasei Medical Co. Ltd., Chiyoda-ku, Tokyo, Japan., Goda Y; Department of Hemo-Vascular Advanced Medicine, Cardiorenal Reseach Laboratory, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Kaneko Y; Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan., Torisu S; Division of Companion Animal Surgery, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido Prefecture, Japan., Tsuruda T; Department of Hemo-Vascular Advanced Medicine, Cardiorenal Reseach Laboratory, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Fujimoto S; M&M Collaboration Research Laboratory, Department of Medical Environment Innovation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Jazyk:	angličtina
Zdroj:	The International journal of artificial organs [Int J Artif Organs] 2024 May; Vol. 47 (5), pp. 321-328. Date of Electronic Publication: 2024 May 13.
DOI:	10.1177/03913988241253152
Abstrakt:	Performance evaluation of new dialysis membranes is primarily performed in vitro, which can lead to differences in clinical results. Currently, data on dialysis membrane performance and safety are available only for haemodialysis patients. Herein, we aimed to establish an in vivo animal model of dialysis that could be extrapolated to humans. We created a bilateral nephrectomy pig model of renal failure, which placed a double-lumen catheter with the hub exposed dorsally. Haemodialysis was performed in the same manner as in humans, during which clinically relevant physiologic data were evaluated. Next, to evaluate the utility of this model, the biocompatibility of two kinds of membranes coated with or without vitamin E used in haemodiafiltration therapy were compared. Haemodialysis treatment was successfully performed in nephrectomized pigs under the same dialysis conditions (4 h per session, every other day, for 2 weeks). In accordance with human clinical data, regular dialysis alleviated renal failure in pigs. The vitamin E-coated membrane showed a significant reduction rate of advanced oxidation protein products during dialysis than non-coated membrane. In conclusion, this model mimics the pathophysiology and dialysis condition of patients undergoing haemodialysis. This dialysis treatment model of renal failure will be useful for evaluating the performance and safety of dialysis membranes. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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