| Autor: |
Nassef NE; Parasitology Department, Faculty of Medicine, Menoufia University, Yassin Abdel Ghaffar St. from Gamal Abdel Nasser St., Shebin El-Kom, Menoufia, Egypt., Shendi SS; Department of Clinical and Molecular Parasitology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt., Saad AE; Department of Clinical and Molecular Parasitology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt., Harba NM; Parasitology Department, Faculty of Medicine, Menoufia University, Yassin Abdel Ghaffar St. from Gamal Abdel Nasser St., Shebin El-Kom, Menoufia, Egypt., Beshay EVN; Parasitology Department, Faculty of Medicine, Menoufia University, Yassin Abdel Ghaffar St. from Gamal Abdel Nasser St., Shebin El-Kom, Menoufia, Egypt., Mohamed ASE; Pathology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt., Gouda MA; Department of Clinical and Molecular Parasitology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt. |
| Abstrakt: |
In the past decade, interest has significantly increased regarding the medicinal and nutritional benefits of pomegranate (Punica granatum) peel. This study examined the effects of using pomegranate peel extract (PGE) alone and in combination with albendazole (ABZ) on ultrastructural and immunological changes in cystic echinococcosis in laboratory-infected mice. Results revealed that the smallest hydatid cyst size and weight (0.48 ± 0.47mm, 0.17 ± 0.18 gm) with the highest drug efficacy (56.2%) was detected in the PGE + ABZ group, which also exhibited marked histopathological improvement. Ultrastructural changes recorded by transmission electron microscopy including fragmentation of the nucleus, glycogen depletion, and multiple lysosomes in vacuolated cytoplasm were more often observed in PGE + ABZ group. IFN-γ levels were significantly increased in the group treated with ABZ, with a notable reduction following PGE treatment, whether administered alone or in combination with ABZ. Thus, PGE enhanced the therapeutic efficiency of ABZ, with improvement in histopathological and ultrastructural changes. |
