Successful Management of Atypical Hemolytic-Uremic Syndrome in Pregnancy Using Eculizumab: A Case Review.
| Autor: | Altaf F; Internal Medicine, BronxCare Health System, Bronx, USA., Khanzada M; Medicine, Lahore Medical and Dental College, Lahore, PAK., Qasim A; Internal Medicine, BronxCare Health System, Bronx, USA., Anto AM; Internal Medicine, BronxCare Health System, Bronx, USA., Haider A; Internal Medicine, St. Vincent Medical Center, Bridgeport, USA., Khaja M; Internal Medicine/Pulmonary Critical Care, Icahn School of Medicine at Mount Sinai, BronxCare Health System, Bronx, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Apr 10; Vol. 16 (4), pp. e57973. Date of Electronic Publication: 2024 Apr 10 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.57973 |
| Abstrakt: | Hemolytic-uremic syndrome (HUS) is a rare thrombotic microangiopathy characterized by the triad of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and acute kidney injury. The disease is pathologically marked by fibrinoid necrosis within renal arterioles and glomerular capillaries. HUS can be categorized into typical variants, often linked to Shiga toxin-producing Escherichia coli (STEC) infection, and atypical variants that stem from dysregulation in the alternative complement pathway. Pregnancy is a recognized predisposing condition for HUS due to the potential reduction in complement regulatory proteins and the possibility of heightened maternal immune response. This report illustrates the case of a 36-year-old woman who, at 36 weeks of gestation, faced a breech presentation and was diagnosed with atypical HUS (aHUS) after placental abruption. Following a cesarean section, she developed complications, including a pelvic hematoma and bilateral hydronephrosis. Despite initial suboptimal response to plasmapheresis, the patient exhibited marked clinical improvement with eculizumab treatment, with no evidence of disease relapse. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Altaf et al.) |
| Databáze: | MEDLINE |
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