Late-Presenting Eosinophilic Granulomatosis with Polyangiitis as Cause of Pulmonary Fibrosis: A Case-Based Review.
| Autor: | Coronado-Sarmiento JF; Faculty of Medicine, Universidad de la Sabana, Chia, Colombia., Coronado-López JP; Health Sciences Faculty, Pontificia Universidad Javeriana, Cali, Colombia., Tuta-Quintero E; Faculty of Medicine, Universidad de la Sabana, Chia, Colombia., Mora CM; Faculty of Medicine, Universidad de la Sabana, Chia, Colombia.; Internal Medicine Department, Universidad de la Sabana, Chia, Colombia., Mayor V; Health Sciences Faculty, Pontificia Universidad Javeriana, Cali, Colombia.; Internal Medicine Department, Universidad del Bosque, Bogota, Colombia. |
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| Jazyk: | angličtina |
| Zdroj: | Mediterranean journal of rheumatology [Mediterr J Rheumatol] 2024 Feb 12; Vol. 35 (1), pp. 172-178. Date of Electronic Publication: 2024 Feb 12 (Print Publication: 2024). |
| DOI: | 10.31138/mjr.161023.lpe |
| Abstrakt: | Introduction: Eosinophilic granulomatosis with polyangiitis (eGPA) is a necrotising vasculitis of small and medium calibre vessels, which affects mostly patients in their fourth to sixth decade of life, and it is a very uncommon aetiology for pulmonary fibrosis. Clinical Case: A Hispanic 72-year-old female patient presents with a history of lower extremities pain, paraesthesia, oedema, and occasional macroscopic haematuria. During her hospitalisation, the patient presents, and images showed findings compatible with pulmonary fibrosis and alveolar haemorrhage, which require a biopsy, establishing the diagnosis of an eGPA. Discussion: eGPA is a low-incidence autoimmune vasculitis, with a high number of phenotypes which explain the broad clinical spectrum, but recent advances has helped to understand the physiopathology and its link with other conditions like pulmonary fibrosis. Conclusion: Early diagnosis and management of this condition is mandatory because it is the only factor that change the outcome of the patients. Competing Interests: The authors declare no have any conflict of interest. (© 2024 The Mediterranean Journal of Rheumatology (MJR).) |
| Databáze: | MEDLINE |
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