Evaluation of microalbuminuria in type-2 diabetes mellitus under oral hypoglycemic agents: Association with age, sex, BMI, and renal clearance.

Autor: Gnanasegaran S; Department of Pharmacology, Vinayaka Mission's Medical College and Hospital, Karaikal, Vinayaka Mission's Research Foundation (DU), Puducherry, India., Gopal S; Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Science, Puducherry, India., Adhimoolam M; Department of Pharmacology, Sri Venkateshwaraa Medical College Hospital and Research Centre, Pondicherry University, Ariyur, Puducherry, India., Raj GM; Department of Pharmacology, All India Institute of Medical Sciences (AIIMS) Bibinagar, Hyderabad, Telangana, India., Velayudhan S; Department of Biochemistry, Vinayaka Mission's Medical College and Hospital, Karaikal, Vinayaka Mission's Research Foundation (DU), Puducherry, India., Yuvaraj M; Department of Anatomy, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: Journal of family medicine and primary care [J Family Med Prim Care] 2024 Mar; Vol. 13 (3), pp. 938-943. Date of Electronic Publication: 2024 Apr 04.
DOI: 10.4103/jfmpc.jfmpc_1286_23
Abstrakt: Background: Diabetes mellitus (DM) is increasing drastically and affecting the individuals globally, especially in the low- and middle-income countries like India. The poor glycaemic control results in micro-vascular and macro-vascular complications, leading to dysfunction of multiple organs. This study aimed to evaluate the association between the risk factors and microalbuminuria levels among patients with type 2 DM on oral hypoglycaemic agents.
Materials and Methods: Hundred type 2 DM patients fulfilling the inclusion and exclusion criteria were selected by convenient random sampling. Demographic details, biochemical markers, and anti-diabetic medication details were collected. The findings were analyzed statistically using Chi-square test and one-way analysis of variance (ANOVA) with SPSS software 21.0.
Results: Among the different combination therapies, 59% were commonly using metformin and teneligliptin. There was a significant association noted between microalbuminuria and risk factors like age, duration of disease, body mass index (BMI) (25.5 ± 2.9), fasting blood sugar (151 ± 53.2 mg/dL), post prandial blood sugar (227.01 ± 70.9 mg/dL), blood urea (24.42 ± 9.3 mg/dL), and serum creatinine (1.5 ± 0.2 mg/dL) ( P < 0.001). One-way ANOVA showed statistical significance between microalbuminuria and the different treatment groups ( P < 0.0001).
Conclusion: Microalbuminuria was associated with age, duration of diabetes, glycaemic control, and BMI. In contrast, there was no significant difference noted between the genders and microalbuminuria. Microalbuminuria is an early indication of nephropathy in diabetes patients. The early identification of the risk factors is important, and it is always recommended to screen for microalbuminuria in all the diabetic patients for early detection and prevention of diabetic nephropathy and their associated complications.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2024 Journal of Family Medicine and Primary Care.)
Databáze: MEDLINE
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