Successful Fistula Closure After Treatment with Colostomy and Infliximab in a Patient with Ulcerative Colitis Complicated by Rectovaginal Fistula.

Autor:	Katsube S; Department of Gastroenterology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Matsumoto S; Department of Gastroenterology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Misawa M; Department of Obstetrics and Gynecology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Kakizawa N; Department of General and Gastrointestinal Surgery, Jichi Medical University Saitama Medical Center, Saitama, Japan., Hashimoto R; Department of Gastroenterology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Mizutani T; Department of Gastroenterology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Matsumoto K; Department of Gastroenterology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Yoshikawa S; Department of Gastroenterology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Mashima H; Department of Gastroenterology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Jazyk:	angličtina
Zdroj:	Biologics : targets & therapy [Biologics] 2024 May 06; Vol. 18, pp. 107-113. Date of Electronic Publication: 2024 May 06 (Print Publication: 2024).
DOI:	10.2147/BTT.S457300
Abstrakt:	The patient was a 50-year-old Japanese woman who was diagnosed with total-colitis-type ulcerative colitis (UC) at the age of 26 years. She was treated with mesalazine and azathioprine, and her disease activity was well controlled. At the age of 50 years, the patient was experiencing fever, abdominal pain, diarrhea, bloody stool, and anal pain, which led to a diagnosis of a relapse of UC. Although steroid therapy was administered and tended to improve her symptoms, fecaloid vaginal discharge occurred, and rectovaginal fistula (RVF) was confirmed. Colostomy was performed, and infliximab was initiated as maintenance therapy for UC. All symptoms improved, and RVF closure was confirmed 6 months after the initiation of infliximab. To date, she has been free from relapse of UC. There have been only a few reports of UC complicated by RVF, and this condition is often difficult to treat. To the best of our knowledge, no other case of UC complicated by RVF in which the fistula was closed after treatment with colostomy and infliximab has been previously reported; thus, our report of the present case is valuable to the literature. Competing Interests: The authors report no conflicts of interest in this work. (© 2024 Katsube et al.)
Databáze:	MEDLINE
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