A historical narrative review through the field of tocolysis in threatened preterm birth.

Autor:	van Winden T; Amsterdam UMC, location University of Amsterdam, Obstetrics and Gynecology, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands.; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of General Practice, Amsterdam Public Health Research Institute, Boelelaan 1117, Amsterdam, the Netherlands., Roos C; Amsterdam UMC, location University of Amsterdam, Obstetrics and Gynecology, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands., Mol BW; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia., Pajkrt E; Amsterdam UMC, location University of Amsterdam, Obstetrics and Gynecology, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands., Oudijk MA; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands.; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Obstetrics and Gynecology, the Netherlands.
Jazyk:	angličtina
Zdroj:	European journal of obstetrics & gynecology and reproductive biology: X [Eur J Obstet Gynecol Reprod Biol X] 2024 Apr 29; Vol. 22, pp. 100313. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024).
DOI:	10.1016/j.eurox.2024.100313
Abstrakt:	Preterm birth presents a significant challenge in clinical obstetrics, requiring effective strategies to reduce associated mortality and morbidity risks. Tocolytic drugs, aimed at inhibiting uterine contractions, are a key aspect of addressing this challenge. Despite extensive research over many years, determining the most effective tocolytic agents remains a complex task, prompting better understanding of the underlying mechanisms of spontaneous preterm birth and recording meaningful outcome measures. This paper provides a comprehensive review of various obsolete and current tocolytic drug regimens that were instituted over the past century, examining both historical contexts and contemporary challenges in their development and adoption. The examination of historical debates and advancements highlights the complexity of introducing new therapies. While the search for effective tocolytics continues, questions arise regarding their actual benefits in obstetric care and the necessity for ongoing exploration. The presence of methodological limitations in current research emphasizes the importance of well-designed randomized controlled trials with robust endpoints and extended follow-up periods.In response to these complexities, the consideration of shifting towards prevention strategies aimed at addressing the root causes of preterm labor becomes more and more evident. This potential shift may offer a more effective approach than relying solely on tocolytics to delay labor initiation.Ultimately, effectively managing threatened preterm birth necessitates ongoing investigation, innovation, and a willingness to reassess strategies in pursuit of optimal outcomes for mothers, neonates, and long-term child health. Competing Interests: The authors have no conflicts of interest. (© 2024 The Authors.)
Databáze:	MEDLINE
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