Direct sub-atmospheric pressure ionization mass spectrometry: Evaporation/sublimation-driven ionization is amazing, fundamentally, and practically.

Autor:	Trimpin S; Department of Chemistry, Wayne State University, Detroit, Michigan, USA.; MSTM, LLC, Newark, Delaware, USA., Inutan ED; Department of Chemistry, Wayne State University, Detroit, Michigan, USA.; MSTM, LLC, Newark, Delaware, USA.; Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines., Pagnotti VS; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Karki S; Department of Chemistry, Wayne State University, Detroit, Michigan, USA.; MSTM, LLC, Newark, Delaware, USA., Marshall DD; Department of Chemistry, Wayne State University, Detroit, Michigan, USA.; MSTM, LLC, Newark, Delaware, USA., Hoang K; MSTM, LLC, Newark, Delaware, USA.; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Wang B; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Lietz CB; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Richards AL; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Yenchick FS; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Lee C; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Lu IC; Department of Chemistry, Wayne State University, Detroit, Michigan, USA.; Department of Chemistry, National Chung Hsing University, Taichung, Taiwan., Fenner M; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Madarshahian S; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Saylor S; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Chubatyi ND; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Zimmerman T; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Moreno-Pedraza A; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Wang T; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Adeniji-Adele A; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Meher AK; Department of Chemistry, Wayne State University, Detroit, Michigan, USA.; MSTM, LLC, Newark, Delaware, USA., Madagedara H; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Owczarzak Z; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Musavi A; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Hendrickson TL; Department of Chemistry, Wayne State University, Detroit, Michigan, USA., Peacock PM; First State IR, LLC, Hockessin, Delaware, USA., Tomsho JW; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., Larsen BS; MSTM, LLC, Newark, Delaware, USA., Prokai L; Department of Pharmacology and Neuroscience, The University of North Texas Health Science Center at Forth Worth, Fort Worth, Texas, USA., Shulaev V; Department of Biological Sciences, The University of North Texas, Denton, Texas, USA., Pophristic M; MSTM, LLC, Newark, Delaware, USA.; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA., McEwen CN; MSTM, LLC, Newark, Delaware, USA.; Department of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	Journal of mass spectrometry : JMS [J Mass Spectrom] 2024 Jun; Vol. 59 (6), pp. e5018.
DOI:	10.1002/jms.5018
Abstrakt:	This paper covers direct sub-atmospheric pressure ionization mass spectrometry (MS). The discovery, applications, and mechanistic aspects of novel ionization processes for use in MS that are not based on the high-energy input from voltage, laser, and/or high temperature but on sublimation/evaporation within a region linking a higher to lower pressure and modulated by heat and collisions, are discussed, including how this new reality has guided a series of discoveries, instrument developments, and commercialization. A research focus, inter alia, is on how best to understand, improve, and use these novel ionization processes, which convert volatile and nonvolatile compounds from solids (sublimation) or liquids (evaporation) into gas-phase ions for analysis by MS providing reproducible, accurate, sensitive, and prompt results. Our perception on how these unprecedented versus traditional ionization processes/methods relate to each other, how they can be made to coexist on the same mass spectrometer, and an outlook on new and expanded applications (e.g., clinical, portable, fast, safe, and autonomous) is presented, and is based on ST's Opening lecture presentation at the Nordic Mass spectrometry Conference, Geilo, Norway, January 2023. Focus will be on matrix-assisted ionization (MAI) and solvent-assisted ionization (SAI) MS covering the period from 2010 to 2023; a potential paradigm shift in the making. (© 2024 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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