Photodynamic therapy for the treatment of port-wine stains in phakomatosis pigmentovascularis.

Autor: Huang Y; Department of Dermatology and Venereology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China., Yang J; Department of Dermatology and Venereology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Bi M; Department of Dermatology and Venereology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Wang L; Department of Dermatology and Venereology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Ju W; Department of General Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Liu X; Department of General Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Bi L; Department of Dermatology and Venereology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China., Du Y; Department of Dermatology and Venereology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China., Chen B; Department of Dermatology and Venereology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China., Fan W; Department of Dermatology and Venereology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 Sep; Vol. 23 (9), pp. 2888-2894. Date of Electronic Publication: 2024 May 12.
DOI: 10.1111/jocd.16351
Abstrakt: Background: Phakomatosis pigmentovascularis (PPV) is a rare congenital syndrome. Only a few studies have reported the treatment of PPV, including a case using photodynamic therapy (PDT) to treat PPV-associated port-wine stains (PWS).
Objective: To investigating the efficacy and adverse effects of hemoporfin-PDT in PPV-associated PWS.
Methods: The efficacy and adverse effects in patients with PPV who underwent two sessions of hemoporfin-PDT from January 2019 to December 2022 were retrospectively analyzed.
Results: Twenty patients were included (13 females, 7 males, age range: 2-31 years; mean: 8.20 ± 8.92 years). Two, nine, seven, and two patients had PPV types Ia, IIa, IIb, and IIIa, respectively. After two treatments, the visual evaluation indicated the color of the PWS in 4, 5, 6, and 5 patients showed poor, fair, good, and excellent improvements, respectively. The combined good and excellent improvement rates in patients with PWS and pigmentary nevus overlapping in the same treatment area and in patients with PWS in the treatment areas only were 33.3% versus 87.5%, respectively, and were significantly different (p = 0.02). Minor side effects, such as edema, scabbing, hyperpigmentation, and blistering, were observed in some patients after PDT.
Conclusion: Hemoporfin-PDT is an effective treatment for PPV-associated PWS. Patients with PWS and pigmentary nevus overlapping in the same treatment area showed poorer efficacy than patients with PWS in the treatment areas only.
(© 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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