Sympathetic Neurofunction Testing in Gestational Hypertension and Relationship with Developing Preeclampsia and Eclampsia: Real-world Evidences from Clinical Pharmacology Clinics.

Autor:	Samajdar SS; Clinical Pharmacologist and Consultant at Diabetes and Allergy-Asthma Therapeutics Specialty Clinic, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India, Corresponding Author., Sarkar S; Clinical Pharmacologist and Consultant at Diabetes and Allergy-Asthma Therapeutics Specialty Clinic, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India., Bhadra A; Assistant Professor, Department of Gynaecology and Obstetrics, Medical College and Hospital, Kolkata, West Bengal, India., Mukherjee S; PhD Scholar Pharmacology, COVOVAX NOVOVAX Phase 3 Clinical Trial ICMR, Kolkata, West Bengal, India., Saha D; Post Doctoral Trainee COVOVAX NOVOVAX Phase 3 Clinical Trial ICMR, Kolkata, West Bengal, India., Das A; Research Assistant COVOVAX NOVOVAX Phase 3 Clinical Trial ICMR, Kolkata, West Bengal, India., Sen S; Clinical Pharmacologist, Department of Clinical & Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India., Tripathi SK; Clinical Pharmacologist Academic Dean, Department of Pharmacology, Netaji Subhas Medical College and Hospital, Patna, Bihar, India., Pal J; Professor, Department of Medicine, R G Kar Medical College and Hospital, Kolkata, West Bengal, India., Joshi SR; Senior Endocrinologist, Department of Endocrinology, Joshi Clinic, Mumbai, Maharashtra, India.
Jazyk:	angličtina
Zdroj:	The Journal of the Association of Physicians of India [J Assoc Physicians India] 2024 Mar; Vol. 72 (3), pp. 47-50.
DOI:	10.59556/japi.72.0484
Abstrakt:	Background: Gestational hypertension carries a high-risk for adverse maternal and fetal outcomes, and it can also develop into preeclampsia. A relative decrease in parasympathetic and increase in sympathetic activity has been seen in normal pregnancy which returns to baseline after delivery. The present study aimed to detect any abnormality in sympathetic neurofunction in gestational hypertension and to identify its possible association with the development of preeclampsia/eclampsia. Methods: A prospective, observational study was carried out among gestational hypertensive patients between 24 and 26 weeks of gestation, who were sent to clinical pharmacology clinics for autonomic neurofunction testing, along with their 24-hour urinary protein testing reports. Preisometric handgrip (IHG) and post-IHG differences in diastolic blood pressure (DBP) were noted. The association between Δ DBP and the development of eclampsia/preeclampsia was probed. Results: A total of 52 pregnancy-induced hypertension (PIH) participants, both multigravida ( n = 15) and primigravida ( n = 37) were included in one arm (PIH arm), and 52 matched (age and gravida) pregnant women, those do not have PIH included in another arm for comparative analysis. On comparing the PIH arm and normal arm, prehand grip DBP ( p ≤ 0.0001), posthand grip DBP, and Δ DBP were significantly higher in the PIH arm. Correlation between Δ DBP and 24 hours' proteinuria was observed in the PIH arm, with a significant positive correlation. Conclusion: A high-rise in DBP post-IHG exercise is associated with gestational hypertensive mothers and this rise is strongly correlated with the development of preeclampsia and eclampsia, which suggests that addressing sympathetic hyperactivity could be a potential area to target therapeutics while managing gestational hypertension. (© Journal of the Association of Physicians of India 2024.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu