A Novel Gene Fusion YLPM1::PRKD1 Identified in a Cribriform Subtype of Polymorphous Adenocarcinoma.

Autor: Miyakawa-Liu M; Department of Pathology, Stanford University School of Medicine, Stanford, USA. mmiyakaw@stanford.edu., Ozawa MG; Department of Pathology, Stanford University School of Medicine, Stanford, USA., Chen M; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, USA., Rahman M; Department of Pathology, Stanford University School of Medicine, Stanford, USA.
Jazyk: angličtina
Zdroj: Head and neck pathology [Head Neck Pathol] 2024 May 13; Vol. 18 (1), pp. 43. Date of Electronic Publication: 2024 May 13.
DOI: 10.1007/s12105-024-01648-z
Abstrakt: Cribriform adenocarcinoma of the salivary gland (CASG) is an entity that is currently classified under polymorphous adenocarcinoma (PAC), cribriform subtype per the 2022 WHO classification of head and neck tumours. There is debate about whether CASG should be considered a separate diagnostic entity, as CASG differs from conventional PAC in anatomic site, clinical behaviors, and molecular patterns. Herein we describe a challenging and unique case which shares histologic and behavioral features between CASG and conventional PAC with a YLPM1::PRKD1 rearrangement not previously reported in the literature.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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