Intratracheal instillation of budesonide suspension versus normal saline on oxidative stress in neonates with meconium aspiration syndrome.
| Autor: | Qiu A; Neonatology Department, Huai'an Maternal and Child Health Care Center, Huai'an, Jiangsu, P. R. China., Wang J; Neonatology Department, Huai'an Maternal and Child Health Care Center, Huai'an, Jiangsu, P. R. China., Yang L; Neonatology Department, Huai'an Maternal and Child Health Care Center, Huai'an, Jiangsu, P. R. China., Lu X; Neonatology Department, Huai'an Maternal and Child Health Care Center, Huai'an, Jiangsu, P. R. China., Zhang W; Neonatology Department, Huai'an Maternal and Child Health Care Center, Huai'an, Jiangsu, P. R. China., Pan Z; Neonatology Department, Huai'an Maternal and Child Health Care Center, Huai'an, Jiangsu, P. R. China. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2024 Dec; Vol. 37 (1), pp. 2337708. Date of Electronic Publication: 2024 May 12. |
| DOI: | 10.1080/14767058.2024.2337708 |
| Abstrakt: | Background: Presently, the efficacy of neonatal resuscitation techniques via interventions such as oral, nasal, and endotracheal suction for preventing meconium aspiration syndrome (MAS) after delivery has not been satisfactory. Objective: This study aimed to investigate the role of intratracheal instillation of budesonide on oxidative stress in MAS. Methods: Sixty-two neonates with MAS admitted to Huai'an Maternity and Child Healthcare Hospital from January 2018 to June 2020 were divided into a study group (intratracheal instillation of 2 ml budesonide suspension; n = 31) and a control group (intratracheal instillation of 2 ml normal saline; n = 31). Collect data from two groups of patients and evaluate clinical outcomes, including oxygenation index (OI), as well as serum total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI) and 8-Isoprostane before treatment and 72h after admission. Results: We found no statistical differences in mortality, complication rate, total oxygen inhalation time, OI before treatment and 72h after admission between the two groups of neonates with MAS, while the duration of invasive respiratory support in the study group was significantly shorter than in the control group. Also, serum TAC, TOS, OSI and 8-isoprostane levels were not statistically different before treatment between the two groups. After 72h of admission, OSI and 8-Isoprostane in neonates with MAS in the study group were much lower than those in the control group. TOS, OSI, 8-Isoprostane in the control group and 8-Isoprostane in the study group were significantly higher than those before treatment. As for TAC and TOS, no significant differences were observed between the two groups. Conclusion: Intratracheal instillation of budesonide was shown to alleviate oxidative stress and shorten invasive ventilation time in neonates with MAS. |
| Databáze: | MEDLINE |
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