In vitro and in vivo anthelmintic effect of essential oil obtained from Thymus capitatus flowers against Haemonchus contortus and Heligmosomoides polygyrus.
Autor: | Amel A; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020, Sidi Thabet, Tunisia; Faculty of Sciences of Tunis, University of Tunis El Manar, 2092, Manar II, Tunis, Tunisia. Electronic address: amelabidi12@hotmail.fr., Sebai E; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020, Sidi Thabet, Tunisia., Mhadhbi M; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020, Sidi Thabet, Tunisia., Akkari H; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020, Sidi Thabet, Tunisia. |
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Jazyk: | angličtina |
Zdroj: | Experimental parasitology [Exp Parasitol] 2024 Jul; Vol. 262, pp. 108778. Date of Electronic Publication: 2024 May 11. |
DOI: | 10.1016/j.exppara.2024.108778 |
Abstrakt: | Sheep haemonchosis is a disease that causes serious losses in livestock production, particularly with the increase of cases of anthelmintic resistance around the world. This justifies the urgent need of alternative solutions. The aim of this study was to determine the chemical profile, in vitro, and, in vivo, anthelmintic properties of Thymus capitatus essential oil. To evaluate the, in vitro, anthelmintic activity of the T. capitatus EO on Haemonchus contortus, two tests were used: egg hatch assay (EHA) and adult worm motility (AWM) assay. The nematicidal effect of this oil was evaluated, in vivo, in mice infected artificially with Heligmosomoides polygyrus using faecal egg count reduction (FECR) and total worm count reduction (TWCR). Chromatographic characterization of T.capitatus composition using gas chromatography coupled to mass spectrometry (GC-MS) demonstrated the presence of carvacrol (81.16%), as the major constituents. The IC Competing Interests: Declaration of competing interest On behalf the co-authors, we declare no conflicts of interest in relation to this work. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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