Boarding pyroptosis onto nanotechnology for cancer therapy.

Autor: Ban W; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China., Chen Z; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China., Zhang T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China., Du T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China., Huo D; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China., Zhu G; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China., He Z; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China., Sun J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China. Electronic address: sunjin@syphu.edu.cn., Sun M; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China. Electronic address: sunmengchi@syphu.edu.cn.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Jun; Vol. 370, pp. 653-676. Date of Electronic Publication: 2024 May 15.
DOI: 10.1016/j.jconrel.2024.05.014
Abstrakt: Pyroptosis, a non-apoptotic programmed cellular inflammatory death mechanism characterized by gasdermin (GSDM) family proteins, has gathered significant attention in the cancer treatment. However, the alarming clinical trial data indicates that pyroptosis-mediated cancer therapeutic efficiency is still unsatisfactory. It is essential to integrate the burgeoning biomedical findings and innovations with potent technology to hasten the development of pyroptosis-based antitumor drugs. Considering the rapid development of pyroptosis-driven cancer nanotherapeutics, here we aim to summarize the recent advances in this field at the intersection of pyroptosis and nanotechnology. First, the foundation of pyroptosis-based nanomedicines (NMs) is outlined to illustrate the reliability and effectiveness for the treatment of tumor. Next, the emerging nanotherapeutics designed to induce pyroptosis are overviewed. Moreover, the cross-talk between pyroptosis and other cell death modalities are discussed, aiming to explore the mechanistic level relationships to provide guidance strategies for the combination of different types of antitumor drugs. Last but not least, the opportunities and challenges of employing pyroptosis-based NMs in potential clinical cancer therapy are highlighted.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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