Rodent and broiler feeding studies with maize containing genetically modified event DP-915635-4 show no adverse effects on health or performance.

Autor: Smith BL; Corteva Agriscience, Johnston, IA, USA. Electronic address: Brenda.Smith@corteva.com., Carlson AB; Corteva Agriscience, Johnston, IA, USA., Fallers MN; Corteva Agriscience, Newark, DE, USA., Crumplar SS; Corteva Agriscience, Newark, DE, USA., Zimmermann CS; Corteva Agriscience, Johnston, IA, USA., Mathesius CA; Corteva Agriscience, Johnston, IA, USA., Mukerji P; Corteva Agriscience, Newark, DE, USA., McNaughton JL; AHPharma, Inc., Hebron, MD, USA., Herman RA; Corteva Agriscience, Indianapolis, IN, USA.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Jul; Vol. 189, pp. 114716. Date of Electronic Publication: 2024 May 11.
DOI: 10.1016/j.fct.2024.114716
Abstrakt: Several regulatory agencies continue to require animal feeding studies to approve new genetically modified crops despite such studies providing little value in the safety assessment. Feeding studies with maize grain containing event DP-915635-4 (DP915635), a new corn rootworm management trait, were conducted to fulfill that requirement. Diets fed to Crl:CD®(SD) rats for 90 days contained up to 50% ground maize grain from DP915635, non-transgenic control, or non-transgenic reference hybrids (P1197, 6158, and 6365). Ross 708 broilers received phase diets containing up to 67% maize grain from each source for 42 days. Growth performance was compared between animals fed DP915635 and control diets; rats were further evaluated for clinical and neurobehavioral measures, ophthalmology, clinical pathology, organ weights, and gross and microscopic pathology, whereas carcass parts and select organ yields were determined for broilers. Reference group inclusion assisted in determining natural variation influence on observed significant differences between DP915635 and control groups. DP915635 maize grain diet consumption did not affect any measure evaluated in either feeding study. Results demonstrated DP-915635-4 maize grain safety and nutritional equivalency when fed in nutritionally adequate diets, adding to the existing literature confirming the lack of significant effects of feeding grain from genetically modified plants.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: James McNaughton reports financial support was provided by Corteva Agriscience. Brenda L. Smith reports a relationship with Corteva Agriscience that includes: employment. Anne B. Carlson reports a relationship with Corteva Agriscience that includes: employment and equity or stocks. Melissa N. Fallers reports a relationship with Corteva Agriscience that includes: employment and equity or stocks. Sarah S. Crumplar reports a relationship with Corteva Agriscience that includes: employment and equity or stocks. Cindi S. Zimmermann reports a relationship with Corteva Agriscience that includes: employment. Carey A. Mathesius reports a relationship with Corteva Agriscience that includes: employment. Pushkor Mukerji reports a relationship with Corteva Agriscience that includes: employment. Rod A. Herman reports a relationship with Corteva Agriscience that includes: employment.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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