Late-in-life Exercise Ameliorates the Aging Trajectory Metabolism Programmed by Maternal Obesity in Rats: It is Never Too Late.
Autor: | Bautista CJ; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga 15, Belisario Domínguez, Tlalpan, Mexico City, Mexico., Reyes-Castro LA; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga 15, Belisario Domínguez, Tlalpan, Mexico City, Mexico., Lomas-Soria C; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga 15, Belisario Domínguez, Tlalpan, Mexico City, Mexico; Consejo Nacional de Humanidades, Ciencias y Tecnologías, Cátedras Investigador por México, Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico., Ibáñez CA; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga 15, Belisario Domínguez, Tlalpan, Mexico City, Mexico., Zambrano E; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga 15, Belisario Domínguez, Tlalpan, Mexico City, Mexico; Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address: elena.zambranog@incmnsz.mx. |
---|---|
Jazyk: | angličtina |
Zdroj: | Archives of medical research [Arch Med Res] 2024 May 11; Vol. 55 (4), pp. 103002. Date of Electronic Publication: 2024 May 11. |
DOI: | 10.1016/j.arcmed.2024.103002 |
Abstrakt: | Background: Maternal obesity (MO) has been shown to adversely affect metabolic, oxidative, reproductive, and cognitive function in offspring. However, it is unclear whether lifestyle modification can ameliorate the metabolic and organ dysfunction programmed by MO and prevent the effects of metabolic syndrome in adulthood. This study aimed to evaluate whether moderate voluntary exercise in the offspring of rats born to obese mothers can ameliorate the adverse effects of MO programming on metabolism and liver function in mid-adulthood. Methods: Offspring of control (CF1) and MOF1 mothers were fed with a control diet from weaning. Adult males and females participated in 15 min exercise sessions five days/week. Metabolic parameters were analyzed before and after the exercise intervention. Liver oxidative stress biomarkers and antioxidant enzymes were analyzed before and after the intervention. Results: Males showed that CF1 Conclusion: These findings suggest that moderate voluntary exercise, even when started in mid-adulthood, can improve metabolic outcomes and delay accelerated metabolic aging in MO-programmed rats in a sex-dependent manner. Competing Interests: Conflict of Intetest The authors have no relevant interests to declare. (Copyright © 2024 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |