Per- and polyfluoroalkyl substances (PFAS) and fetal growth: A nation-wide register-based study on PFAS in drinking water.

Autor: Säve-Söderbergh M; Risk- and Benefit Assessment Department, Swedish Food Agency, Uppsala, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: melle.save-soderbergh@slv.se., Gyllenhammar I; Risk- and Benefit Assessment Department, Swedish Food Agency, Uppsala, Sweden., Schillemans T; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Lindfeldt E; Risk- and Benefit Assessment Department, Swedish Food Agency, Uppsala, Sweden., Vogs C; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden., Donat-Vargas C; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Barcelona Intitute for Global Health (ISGlobal), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Halldin Ankarberg E; Risk- and Benefit Assessment Department, Swedish Food Agency, Uppsala, Sweden., Glynn A; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden., Ahrens L; Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden., Helte E; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Åkesson A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2024 May; Vol. 187, pp. 108727. Date of Electronic Publication: 2024 May 08.
DOI: 10.1016/j.envint.2024.108727
Abstrakt: Background: There is inconclusive evidence for an association between per- and polyfluoroalkyl substances (PFAS) and fetal growth.
Objectives: We conducted a nation-wide register-based cohort study to assess the associations of the estimated maternal exposure to the sum (PFAS4) of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorohexane sulfonic acid (PFHxS) with birthweight as well as risk of small- (SGA) and large-for-gestational-age (LGA).
Materials and Methods: We included all births in Sweden during 2012-2018 of mothers residing ≥ four years prior to partus in localities served by municipal drinking water where PFAS were measured in raw and drinking water. Using a one-compartment toxicokinetic model we estimated cumulative maternal blood levels of PFAS4 during pregnancy by linking residential history, municipal PFAS water concentration and year-specific background serum PFAS concentrations in Sweden. Individual birth outcomes and covariates were obtained via register linkage. Mean values and 95 % confidence intervals (CI) of β coefficients and odds ratios (OR) were estimated by linear and logistic regressions, respectively. Quantile g-computation regression was conducted to assess the impact of PFAS4 mixture.
Results: Among the 248,804 singleton newborns included, no overall association was observed for PFAS4 and birthweight or SGA. However, an association was seen for LGA, multivariable-adjusted OR 1.08 (95% CI: 1.01-1.16) when comparing the highest PFAS4 quartile to the lowest. These associations remained for mixture effect approach where all PFAS, except for PFOA, contributed with a positive weight.
Discussions: We observed an association of the sum of PFAS4 - especially PFOS - with increased risk of LGA, but not with SGA or birthweight. The limitations linked to the exposure assessment still require caution in the interpretation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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