Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder.

Autor: Xu K; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhao S; Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Lab of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, China., Ren Y; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhong Q; Institute of Life Sciences, Chongqing Medical University, Chongqing, China., Feng J; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Tu D; Department of Clinical Laboratory, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Wu W; Institute of Life Sciences, Chongqing Medical University, Chongqing, China., Wang J; Institute of Life Sciences, Chongqing Medical University, Chongqing, China., Chen J; Institute of Life Sciences, Chongqing Medical University, Chongqing, China. chenjianjun@cqmu.edu.cn., Xie P; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. xiepeng@cqmu.edu.cn.; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. xiepeng@cqmu.edu.cn.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2024 May 11; Vol. 14 (1), pp. 202. Date of Electronic Publication: 2024 May 11.
DOI: 10.1038/s41398-024-02916-w
Abstrakt: The pathogenesis of major depressive disorder (MDD) involves lipid metabolism. Our earlier research also revealed that MDD patients had much lower total cholesterol (TC) concentrations than healthy controls (HCs). However, it is still unclear why TC decreased in MDD. Here, based on the Ingenuity Knowledge Base's ingenuity pathway analysis, we found that sodium voltage-gated channel alpha subunit 11A (SCN11A) might serve as a link between low lipid levels and MDD. We analyzed the TC levels and used ELISA kits to measure the levels of SCN11A in the serum from 139 MDD patients, and 65 HCs to confirm this theory and explore the potential involvement of SCN11A in MDD. The findings revealed that TC levels were considerably lower and SCN11A levels were remarkably increased in MDD patients than those in HCs, while they were significantly reversed in drug-treatment MDD patients than in drug-naïve MDD patients. There was no significant difference in SCN11A levels among MDD patients who used single or multiple antidepressants, and selective serotonin reuptake inhibitors or other antidepressants. Pearson correlation analysis showed that the levels of TC and SCN11A were linked with the Hamilton Depression Rating Scales score. A substantial association was also found between TC and SCN11A. Moreover, a discriminative model made up of SCN11A was discovered, which produced an area under a curve of 0.9571 in the training set and 0.9357 in the testing set. Taken together, our findings indicated that SCN11A may serve as a link between low lipid levels and MDD, and showed promise as a candidate biomarker for MDD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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