Self-reported smoking, urine cotinine, and risk of type 2 diabetes: Findings from the PREVEND prospective cohort study.

Autor: Kunutsor SK; Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK. Electronic address: skk31@cantab.net., Tetteh J; Department of Population Health Sciences, University of Leicester, Leicester, UK; Department of Community Health, University of Ghana Medical School, Accra, Ghana., Dey RS; Department of Medicine, University of Ghana Hospital, Legon, Ghana., Touw DJ; Department of Pharmacy and Clinical Pharmacology, University of Groningen and University Medical Center Groningen, the Netherlands., Dullaart RPF; Department of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bakker SJL; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Jazyk: angličtina
Zdroj: Primary care diabetes [Prim Care Diabetes] 2024 Aug; Vol. 18 (4), pp. 414-421. Date of Electronic Publication: 2024 May 11.
DOI: 10.1016/j.pcd.2024.04.004
Abstrakt: Background: Smoking is a major risk factor for type 2 diabetes (T2D), but the evidence has mostly relied on self-reports. We aimed to compare the associations of smoking exposure as assessed by self-reports and urine cotinine with T2D.
Methods: Using the PREVEND prospective study, smoking status was assessed at baseline by self-reports and urine cotinine in 4708 participants (mean age, 53 years) without a history of diabetes. Participants were classified as never, former, light current and heavy current smokers according to self-reports and analogous cut-offs for urine cotinine. Hazard ratios (HRs) with 95% CIs were estimated for T2D.
Results: During a median follow-up of 7.3 years, 259 participants developed T2D. Compared with self-reported never smokers, the multivariable adjusted HRs (95% CI) of T2D for former, light current, and heavy current smokers were 1.02 (0.75-1.4), 1.41 (0.89-2.22), and 1.30 (0.88-1.93), respectively. The corresponding adjusted HRs (95% CI) were 0.84 (0.43-1.67), 1.61 (1.12-2.31), and 1.58 (1.08-2.32), respectively, as assessed by urine cotinine. Urine cotinine-assessed but not self-reported smoking status improved T2D risk prediction beyond established risk factors.
Conclusion: Urine cotinine assessed smoking status may be a stronger risk indicator and predictor of T2D compared to self-reported smoking status.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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