Clinical outcomes with utilization of high-potency topical steroids in patients with lichen sclerosus-associated vulvar cancer.

Autor: Vue NC; Division of Gynecologic Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA. Electronic address: Nujsaubnusi.vue@ahn.org., Sassani J; Division of Urogynecology, Allegheny Health Network, Pittsburgh, PA, USA., Prairie B; Division of Gynecologic Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA., Yin Y; Allegheny Singer Research Institute, Allegheny Health Network, Pittsburgh, PA, USA., Krivak TC; Division of Gynecologic Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA., Crafton S; Division of Gynecologic Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA., Morse C; Division of Gynecologic Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA., Nakayama J; Division of Gynecologic Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA., Wield A; Division of Gynecologic Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA., Horne ZD; Division of Radiation Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA., Miller EM; Division of Gynecologic Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
Jazyk: angličtina
Zdroj: Gynecologic oncology [Gynecol Oncol] 2024 Aug; Vol. 187, pp. 58-63. Date of Electronic Publication: 2024 May 10.
DOI: 10.1016/j.ygyno.2024.05.003
Abstrakt: Objectives: To evaluate the impact of high-potency topical steroid use on risk of recurrence of lichen sclerosus-associated vulvar cancer.
Methods: This is a retrospective cohort study evaluating patients with lichen sclerosus (LS)- associated vulvar squamous cell cancer (VSCC). Demographic and clinical outcome data were compared between two comparison groups: patients who received steroids, mainly clobetasol, and patients who did not receive steroids following treatment of LS-related vulvar cancer. Categorical variables were compared using Fisher's exact test or chi-square test. Continuous variables were compared using a two-sided student's t-test. Time to recurrence (TTR) and overall survival (OS) were analyzed using Kaplan-Meier survival plot and compared using Mantel-Cox log rank test. Cox proportional hazard regression models were conducted to generate hazard ratios for both TTR and OS. A p value of <0.05 was considered statistically significant.
Results: A total of 49 patients were included, with 36 patients receiving steroid treatment and 13 patients in the expectant management group. The median age of diagnosis was 68. The average BMI was 31.7 +/- 7.0. The median length of follow up was 41 months. The majority of patients were diagnosed with stage I VSCC. There was no difference in demographics or oncologic management of vulvar cancer between the two cohorts. Overall recurrence was decreased among patients who received steroid treatment when compared to patients who did not, 12 patients (33.3%) versus 9 patients (69.2%) respectively (p = 0.048).
Conclusions: High-potency topical steroid use following treatment of lichen sclerosus-associated vulvar squamous cell carcinoma is associated with decreased risk of recurrence and prolonged median time to recurrence.
Competing Interests: Declaration of competing interest Dr. Thomas Krivak receives consulting fees, payments, and honoraria from Astra Zeneca, Immunogen, GSK, and Myriad. Dr. Eirwen Miller receives payments and honoraria for lectures from Chemotherapy Foundation Symposium and Gynecologic Malignancies. Dr. Sarah Crafton receives grants/contracts from Mersana Therapeutics and support from the GOG foundation. She serves as part of the Allegheny Health Network Data Safety Monitoring Committee. Dr. John Nakayama receives consulting fees from Astra Zeneca, Xodus Medical and Clovis and payment and honoraria from Merck and Eisai.
(Published by Elsevier Inc.)
Databáze: MEDLINE