Bifunctional oxidase-peroxidase mimicking Fe-Ce MOF on paper-based analytical devices to intensify luminol chemiluminescence: Application for measuring different sugars with a smartphone readout.

Autor: Hassanzadeh J; Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod, 123, Oman., Al Lawati HAJ; Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod, 123, Oman. Electronic address: haiderl@squ.edu.om., Bagheri N; Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod, 123, Oman.
Jazyk: angličtina
Zdroj: Talanta [Talanta] 2024 Aug 15; Vol. 276, pp. 126219. Date of Electronic Publication: 2024 May 07.
DOI: 10.1016/j.talanta.2024.126219
Abstrakt: This study presents a potent paper-based analytical device (PAD) for quantifying various sugars using an innovative bi-nanozyme made from a 2-dimensional Fe/Ce metal-organic framework (FeCe-BTC). The MOF showed excellent bifunctional peroxidase-oxidase activities, efficiently catalyzing luminol's chemiluminescence (CL) reaction. As a peroxidase-like nanozyme, FeCe-BTC could facilitate the dissociation of hydrogen peroxide (H 2 O 2 ) into hydroxyl radicals, which then oxidize luminol. Additionally, it was also discovered that when reacting with H 2 O 2 , the MOF turns into a mixed-valence MOF, and acts as an oxidase nanozyme. This activity is caused by the generated Ce 4+ ions in the structure of MOF that can directly oxidize luminol. The MOF was directly synthesized on the PAD and cascaded with specific natural enzymes to establish simple, rapid, and selective CL sensors for the measurement of different sugars. A cell phone was also used to record light intensities, which were then correlated to the analyte concentration. The designed PAD showed a wide linear range of 0.1-10 mM for glucose, fructose, and sucrose, with detection limits of 0.03, 0.04, and 0.04 mM, respectively. It showed satisfactory results in food and biological samples with recovery values ranging from 95.8 to 102.4 %, which makes it a promising candidate for point-of-care (POC) testing for food control and medicinal purposes.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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