Deleterious mutation/epimutation-selection balance with and without inbreeding: a population (epi)genetics model.

Autor:	Chernomas G; Department of Integrative Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Griswold CK; Department of Integrative Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Jazyk:	angličtina
Zdroj:	Genetics [Genetics] 2024 Jul 08; Vol. 227 (3).
DOI:	10.1093/genetics/iyae080
Abstrakt:	Epigenetics in the form of DNA methylation and other processes is an established property of genotypes and a focus of empirical research. Yet, there remain fundamental gaps in the evolutionary theory of epigenetics. To support a comprehensive understanding of epigenetics, this paper investigates theoretically the combined effects of deleterious mutation and epimutation with and without inbreeding. Both spontaneous epimutation and paramutation are considered to cover a broader range of epigenetic phenomena. We find that inbreeding generally reduces the amount of segregating deleterious genetic and epigenetic variation at equilibrium, although interestingly inbreeding can also increase the amount of deleterious genetic or epigenetic variation. Furthermore, we also demonstrate that epimutation indirectly can cause increased or decreased deleterious genetic variation at equilibrium relative to classic expectations, which is particularly evident when paramutation is occurring. With the addition of deleterious epimutation, there may be significantly increased purging of deleterious variation in more inbred populations and a significantly increased amount of segregating deleterious variation in more outbred populations, with notable exceptions. Competing Interests: Conflicts of interest The authors declare no conflict of interest. (© The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America.)
Databáze:	MEDLINE
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