Particulate matter-induced gene expression patterns in human-derived cells based on 11 public gene expression datasets.
Autor: | Roh S; Department of Medical Science, Soonchunhyang University, Asan, 31538, Korea., Hwang J; Department of Medical IT Engineering, Soonchunhyang University, Asan, 31538, Korea., Park JH; Upper Airway Chronic Inflammatory Diseases Laboratory, Korea University College of Medicine, Seoul, 08308, Korea., Song DJ; Department of Pediatrics, Korea University Guro Hospital, Seoul, 08308, Korea. djsong506@korea.ac.kr., Gim JA; Department of Medical Science, Soonchunhyang University, Asan, 31538, Korea. vitastar@sch.ac.kr. |
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Jazyk: | angličtina |
Zdroj: | Genes & genomics [Genes Genomics] 2024 Jul; Vol. 46 (7), pp. 743-749. Date of Electronic Publication: 2024 May 11. |
DOI: | 10.1007/s13258-024-01512-y |
Abstrakt: | Background: Exposure to particulate matter (PM) and house dust mite (HDM) can change the expression patterns of inflammation-, oxidative stress-, and cell death-related genes. We investigated the changes in gene expression patterns owing to PM exposure. Objective: This study examined the changes in gene expression patterns following PM exposure. Methods: We searched for differentially expressed genes (DEGs) following PM exposure using five cell line-based RNA-seq or microarray datasets and six human-derived datasets. The enrichment terms of the DEGs were assessed. Results: DEG analysis yielded two gene sets. Thus, enrichment analysis was performed for each gene set, and the enrichment terms related to respiratory diseases were presented. The intersection of six human-derived datasets and two gene sets was obtained, and the expression patterns following PM exposure were observed. Conclusions: Two gene sets were obtained for cells treated with PM and their expression patterns were presented following verification in human-derived cells. Our findings suggest that exposure to PM (© 2024. The Author(s) under exclusive licence to The Genetics Society of Korea.) |
Databáze: | MEDLINE |
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