| Autor: |
Clemente A; Radiology Unit, Centro Medicina Nucleare N1, 'Centro Morrone', 81100 Caserta, Italy., Selva G; Radiology Unit, Centro Medicina Nucleare N1, 'Centro Morrone', 81100 Caserta, Italy., Berks M; Quantitative Biomedical Imaging Laboratory, Division of Cancer Sciences, University of Manchester, Manchester M13 9PL, UK., Morrone F; Radiology Unit, Centro Radiologico Vega, 'Centro Morrone', 81100 Caserta, Italy., Morrone AA; Radiology Unit, Centro Radiologico Vega, 'Centro Morrone', 81100 Caserta, Italy., Aulisa MC; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy., Bliakharskaia E; Department of Neuroscience and Imaging, University G. d'Annunzio, 66100 Chieti, Italy., De Nicola A; Radiology Unit, SS. Annunziata Hospital, ASL Lanciano Vasto Chieti, 66100 Chieti, Italy., Tartaro A; Department of Clinical, Oral Sciences and Biotechnology, University 'G. d'Annunzio', 66100 Chieti, Italy.; MRI Unit, Santissima Trinità Hospital, ASL Pescara, 65026 Popoli, Italy., Summers PE; QMRI Tech, 65123 Pescara, Italy. |
| Abstrakt: |
Tofts models have failed to produce reliable quantitative markers for prostate cancer. We examined the differences between prostate zones and lesion PI-RADS categories and grade group (GG) using regions of interest drawn in tumor and normal-appearing tissue for a two-compartment uptake (2CU) model (including plasma volume (v p ), plasma flow (F p ), permeability surface area product (PS), plasma mean transit time (MTT p ), capillary transit time (T c ), extraction fraction (E), and transfer constant (K trans )) and exponential (amplitude (A), arrival time (t 0 ), and enhancement rate (α)), sigmoidal (amplitude (A 0 ), center time relative to arrival time (A 1 - T 0 ), and slope (A 2 )), and empirical mathematical models, and time to peak (TTP) parameters fitted to high temporal resolution (1.695 s) DCE-MRI data. In 25 patients with 35 PI-RADS category 3 or higher tumors, we found F p and α differed between peripheral and transition zones. Parameters F p , MTT p , T c , E, α, A 1 - T 0 , and A 2 and TTP all showed associations with PI-RADS categories and with GG in the PZ when normal-appearing regions were included in the non-cancer GG. PS and K trans were not associated with any PI-RADS category or GG. This pilot study suggests early enhancement parameters derived from ultrafast DCE-MRI may become markers of prostate cancer. |
