| Autor: |
Pozzobon FM; Barra D'Or Hospital, Rede D'Or São Luiz, Rio de Janeiro 22775-002, RJ, Brazil.; Health Assistance Division, Federal Fluminense University (UFF), Niterói 24220-900, RJ, Brazil., Luiz RR; Institute for Collective Health Studies, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-598, RJ, Brazil., Parente JG; Barra D'Or Hospital, Rede D'Or São Luiz, Rio de Janeiro 22775-002, RJ, Brazil., Guarilha TM; Barra D'Or Hospital, Rede D'Or São Luiz, Rio de Janeiro 22775-002, RJ, Brazil., Fontes MPRC; Barra D'Or Hospital, Rede D'Or São Luiz, Rio de Janeiro 22775-002, RJ, Brazil., de Mello Perez R; D'Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil.; School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21044-020, RJ, Brazil., Chindamo MC; Barra D'Or Hospital, Rede D'Or São Luiz, Rio de Janeiro 22775-002, RJ, Brazil.; School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21044-020, RJ, Brazil. |
| Abstrakt: |
Background : Steatotic liver disease (SLD) has been linked to more exacerbated inflammatory responses in various scenarios. The relationship between SLD and COVID-19 prognosis remains unclear. Our aim was to investigate the impact of SLD on the outcome of COVID-19. Methods : Patients hospitalized with confirmed COVID-19 and who underwent laboratory tests and chest CT scans were included. SLD was assessed by measuring the attenuation coefficient on CT scans. The relationship between SLD, the severity of COVID-19 clinical presentation and in-hospital mortality were assessed. Results : A total of 610 patients were included (mean age 62 ± 16 years, 64% male). The prevalence of SLD was 30%, and the overall in-hospital mortality rate was 19%. Patients with SLD were younger (58 ± 13 vs. 64 ± 16 years, p < 0.001) and had a higher BMI (32 ± 5 vs. 28 ± 4 kg/m 2 , p = 0.014). Admission AST values were higher in patients with SLD (82 ± 339 vs. 50 ± 37, p = 0.02), while D-dimer (1112 ± 2147 vs. 1959 ± 8509, p = 0.07), C-reactive protein (12 ± 9 vs. 11 ± 8, p = 0.27), ALT (67 ± 163 vs. 47 ± 90, p = 0.11), ALP (83 ± 52 vs. 102 ± 125, p = 0.27), and GGT (123 ± 125 vs. 104 ± 146, p = 0.61) did not significantly differ compared to patients without SLD. No difference was observed regarding lung parenchyma involvement >50% (20% vs. 17%, p = 0.25), hospital length of stay (14 ± 19 vs. 16 ± 23 days, p = 0.20), hemodialysis support (14% vs. 16%, p = 0.57), use of mechanical ventilation (20% vs. 20%, p = 0.96), and in-hospital mortality (17% vs. 20%, p = 0.40) when comparing patients with and without SLD. Conclusions : SLD showed no significant association with morbidity and mortality in patients with COVID-19. |
