A Multicenter International Retrospective Investigation Assessing the Prognostic Role of Inflammation-Based Scores (Neutrophil-to-Lymphocyte, Lymphocyte-to-Monocyte, and Platelet-to-Lymphocyte Ratios) in Patients with Intermediate-Stage Hepatocellular Carcinoma (HCC) Undergoing Chemoembolizations of the Liver.

Autor: Minici R; Radiology Unit, University Hospital Dulbecco, 88100 Catanzaro, Italy., Venturini M; Diagnostic and Interventional Radiology Unit, ASST Settelaghi, Insubria University, 21100 Varese, Italy., Guzzardi G; Imagerie Vasculaire et Interventionnelle, Centre Hospitalier Princesse Grace, 98000 Monaco, Monaco., Fontana F; Diagnostic and Interventional Radiology Unit, ASST Settelaghi, Insubria University, 21100 Varese, Italy., Coppola A; Diagnostic and Interventional Radiology Unit, ASST Settelaghi, Insubria University, 21100 Varese, Italy., Piacentino F; Diagnostic and Interventional Radiology Unit, ASST Settelaghi, Insubria University, 21100 Varese, Italy., Torre F; Imagerie Vasculaire et Interventionnelle, Centre Hospitalier Princesse Grace, 98000 Monaco, Monaco., Spinetta M; Radiology Unit, Maggiore della Carità University Hospital, 28100 Novara, Italy., Maglio P; Pain Management Unit, University Hospital Dulbecco, 88100 Catanzaro, Italy., Guerriero P; Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy., Ammendola M; Digestive Surgery Unit, University Hospital Dulbecco, 88100 Catanzaro, Italy., Mgjr Research Team; Radiology Unit, University Hospital Dulbecco, 88100 Catanzaro, Italy., Brunese L; Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy., Laganà D; Radiology Unit, University Hospital Dulbecco, 88100 Catanzaro, Italy.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Apr 23; Vol. 16 (9). Date of Electronic Publication: 2024 Apr 23.
DOI: 10.3390/cancers16091618
Abstrakt: Background: The utilization of inflammation-based scores, such as the Neutrophil-to-Lymphocyte Ratio (NLR), Lymphocyte-to-Monocyte Ratio (LMR), and Platelet-to-Lymphocyte Ratio (PLR), has garnered attention for their potential as prognostic indicators in various cancers. However, their predictive role in patients with intermediate-stage HCC undergoing transcatheter arterial chemoembolization (TACE) remains an area that requires further investigation, as early recognition of TACE refractoriness holds the potential to guide tailored therapeutic interventions.
Methods: This multicenter international retrospective study analyzed data from patients with intermediate-stage HCC undergoing TACE between 2018 and 2024. Inflammation-based scores (NLR, LMR, PLR) were assessed preoperatively to predict treatment outcomes.
Results: Two hundred and fourteen patients were enrolled. Preoperative LMR showed the largest area under the curve for the prediction of 6-months PFS, based on the ROC curve analysis. Both high LMR (≥2.24) and low NLR (<4.72) were associated with improved objective response rates and 6-month progression-free survival. Lymphocyte count emerged as a strong predictor of treatment response in both simple ( p < 0.001) and multiple ( p < 0.001) logistic regression analyses.
Conclusions: This study highlights the prognostic value of inflammation-based scores, particularly LMR and NLR, in predicting the treatment response and short-term outcomes of patients with intermediate-stage HCC undergoing TACE. Future investigations should focus on validating these scores' clinical applicability and assessing their impact on long-term patient survival and therapeutic decision-making.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje