Untargeted serum metabolic profiling of diabetes mellitus among Parkinson's disease patients.

Autor: Li S; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Lin Y; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Jones D; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, USA.; Department of Biochemistry, Emory University School of Medicine, Atlanta, USA., Walker DI; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Duarte Folle A; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Del Rosario I; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Yu Y; Center for Health Policy Research, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Zhang K; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Keener AM; Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA., Bronstein J; Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA., Ritz B; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA., Paul KC; Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA. kimberlp@ucla.edu.
Jazyk: angličtina
Zdroj: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 May 10; Vol. 10 (1), pp. 100. Date of Electronic Publication: 2024 May 10.
DOI: 10.1038/s41531-024-00711-4
Abstrakt: Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson's disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resolution metabolomic profiling in serum samples of 636 PD and 253 non-PD participants recruited from Central California. We conducted an initial discovery metabolome-wide association and pathway enrichment analysis. After adjusting for multiple testing, in positive (or negative) ion mode, 30 (25) metabolic features were associated with T2DM in both PD and non-PD participants, 162 (108) only in PD participants, and 32 (7) only in non-PD participants. Pathway enrichment analysis identified 17 enriched pathways associated with T2DM in both the PD and non-PD participants, 26 pathways only in PD participants, and 5 pathways only in non-PD participants. Several amino acid, nucleic acids, and fatty acid metabolisms were associated with T2DM only in the PD patient group suggesting a possible link between PD and T2DM.
(© 2024. The Author(s).)
Databáze: MEDLINE
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