Seasonal variation in D2/3 dopamine receptor availability in the human brain.

Autor: Sun L; Huashan Institute of Medicine, Huashan Hospital, Fudan University, Shanghai, China. lihua.sun@utu.fi.; Turku PET Centre, University of Turku, Turku, Finland. lihua.sun@utu.fi.; Turku PET Centre, Turku University Hospital, Turku, Finland. lihua.sun@utu.fi., Malén T; Turku PET Centre, University of Turku, Turku, Finland.; Turku PET Centre, Turku University Hospital, Turku, Finland., Tuisku J; Turku PET Centre, University of Turku, Turku, Finland.; Turku PET Centre, Turku University Hospital, Turku, Finland., Kaasinen V; Clinical Neurosciences, University of Turku, Turku, Finland.; Turku University Hospital, Neurocenter, Turku, Finland., Hietala JA; Turku PET Centre, University of Turku, Turku, Finland.; Turku PET Centre, Turku University Hospital, Turku, Finland.; Department of Psychiatry, University of Turku, Turku University Hospital, Turku, Finland., Rinne J; Turku PET Centre, University of Turku, Turku, Finland.; Turku PET Centre, Turku University Hospital, Turku, Finland., Nuutila P; Turku PET Centre, University of Turku, Turku, Finland.; Turku PET Centre, Turku University Hospital, Turku, Finland.; Department of Endocrinology, Turku University Hospital, Turku, Finland., Nummenmaa L; Turku PET Centre, University of Turku, Turku, Finland.; Turku PET Centre, Turku University Hospital, Turku, Finland.; Department of Psychology, University of Turku, Turku, Finland.
Jazyk: angličtina
Zdroj: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2024 Sep; Vol. 51 (11), pp. 3284-3291. Date of Electronic Publication: 2024 May 11.
DOI: 10.1007/s00259-024-06715-9
Abstrakt: Purpose: Brain functional and physiological plasticity is essential to combat dynamic environmental challenges. The rhythmic dopamine signaling pathway, which regulates emotion, reward and learning, shows seasonal patterns with higher capacity of dopamine synthesis and lower number of dopamine transporters during dark seasons. However, seasonal variation of the dopamine receptor signaling remains to be characterized.
Methods: Based on a historical database of healthy human brain [ 11 C]raclopride PET scans (n = 291, 224 males and 67 females), we investigated the seasonal patterns of D2/3 dopamine receptor signaling. Daylength at the time of scanning was used as a predictor for brain regional non-displaceable binding of the radiotracer, while controlling for age and sex.
Results: Daylength was negatively correlated with availability of D2/3 dopamine receptors in the striatum. The largest effect was found in the left caudate, and based on the primary sample, every 4.26 h (i.e., one standard deviation) increase of daylength was associated with a mean 2.8% drop (95% CI -0.042 to -0.014) of the receptor availability.
Conclusions: Seasonally varying D2/3 receptor signaling may also underlie the seasonality of mood, feeding, and motivational processes. Our finding suggests that in future studies of brain dopamine signaling, especially in high-latitude regions, the effect of seasonality should be considered.
(© 2024. The Author(s).)
Databáze: MEDLINE
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