Rapid expansion and international spread of M1 UK in the post-pandemic UK upsurge of Streptococcus pyogenes.

Autor: Vieira A; Department of Infectious Disease, Imperial College London, London, UK.; Centre for Bacterial Resistance Biology, Imperial College London, London, UK.; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK., Wan Y; Department of Infectious Disease, Imperial College London, London, UK.; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK.; Healthcare-Associated Infections, Fungal, AMR, AMU, and Sepsis Division, UK Health Security Agency, London, UK., Ryan Y; Reference Services Division, UK Health Security Agency, London, UK., Li HK; Department of Infectious Disease, Imperial College London, London, UK.; Centre for Bacterial Resistance Biology, Imperial College London, London, UK., Guy RL; Healthcare-Associated Infections, Fungal, AMR, AMU, and Sepsis Division, UK Health Security Agency, London, UK., Papangeli M; Department of Infectious Disease, Imperial College London, London, UK.; Centre for Bacterial Resistance Biology, Imperial College London, London, UK., Huse KK; Department of Infectious Disease, Imperial College London, London, UK.; Centre for Bacterial Resistance Biology, Imperial College London, London, UK., Reeves LC; Department of Infectious Disease, Imperial College London, London, UK.; Centre for Bacterial Resistance Biology, Imperial College London, London, UK., Soo VWC; Department of Infectious Disease, Imperial College London, London, UK.; Centre for Bacterial Resistance Biology, Imperial College London, London, UK., Daniel R; Reference Services Division, UK Health Security Agency, London, UK., Harley A; Reference Services Division, UK Health Security Agency, London, UK., Broughton K; Reference Services Division, UK Health Security Agency, London, UK., Dhami C; Reference Services Division, UK Health Security Agency, London, UK., Ganner M; Reference Services Division, UK Health Security Agency, London, UK., Ganner MA; Reference Services Division, UK Health Security Agency, London, UK., Mumin Z; Reference Services Division, UK Health Security Agency, London, UK., Razaei M; Reference Services Division, UK Health Security Agency, London, UK., Rundberg E; Reference Services Division, UK Health Security Agency, London, UK., Mammadov R; Reference Services Division, UK Health Security Agency, London, UK., Mills EA; Department of Infectious Disease, Imperial College London, London, UK.; Centre for Bacterial Resistance Biology, Imperial College London, London, UK., Sgro V; Department of Infectious Disease, Imperial College London, London, UK., Mok KY; Department of Infectious Disease, Imperial College London, London, UK., Didelot X; School of Life Sciences and Department of Statistics, University of Warwick, Coventry, UK., Croucher NJ; School of Public Health, Imperial College London, London, UK.; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK., Jauneikaite E; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK.; School of Public Health, Imperial College London, London, UK.; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK., Lamagni T; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK.; Healthcare-Associated Infections, Fungal, AMR, AMU, and Sepsis Division, UK Health Security Agency, London, UK., Brown CS; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK.; Healthcare-Associated Infections, Fungal, AMR, AMU, and Sepsis Division, UK Health Security Agency, London, UK., Coelho J; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK. Juliana.coelho@ukhsa.gov.uk.; Healthcare-Associated Infections, Fungal, AMR, AMU, and Sepsis Division, UK Health Security Agency, London, UK. Juliana.coelho@ukhsa.gov.uk.; Reference Services Division, UK Health Security Agency, London, UK. Juliana.coelho@ukhsa.gov.uk., Sriskandan S; Department of Infectious Disease, Imperial College London, London, UK. s.sriskandan@imperial.ac.uk.; Centre for Bacterial Resistance Biology, Imperial College London, London, UK. s.sriskandan@imperial.ac.uk.; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK. s.sriskandan@imperial.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 May 10; Vol. 15 (1), pp. 3916. Date of Electronic Publication: 2024 May 10.
DOI: 10.1038/s41467-024-47929-7
Abstrakt: The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1 UK to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1 global strains, invasive M1 UK strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes covRS. The emergence of M1 UK is dated to 2008. Following a bottleneck coinciding with the COVID-19 pandemic, three emergent M1 UK clades underwent rapid nationwide expansion, despite lack of detection in previous years. All M1 UK isolates thus-far sequenced globally have a phylogenetic origin in the UK, with dispersal of the new clades in Europe. While waning immunity may promote streptococcal epidemics, the genetic features of M1 UK point to a fitness advantage in pathogenicity, and a striking ability to persist through population bottlenecks.
(© 2024. The Author(s).)
Databáze: MEDLINE
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