Levels of sCD163 in women rheumatoid arthritis: Relationship with cardiovascular risk markers.

Autor: Zaragoza-García O; Laboratory of Multidisciplinary Research and Biomedical Innovation, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico., Briceño O; Infectious Diseases Research Center, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Villafan-Bernal JR; Laboratory of Immunogenomics and Metabolic Diseases, Instituto Nacional de Medicina Genomica, Mexico City, Mexico., Gutiérrez-Pérez IA; Laboratory of Multidisciplinary Research and Biomedical Innovation, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico., Rojas-Delgado HU; Hospital General Dr. José G. Parres, Cuernavaca, Morelos, Mexico., Alonso-Silverio GA; Laboratory of Multidisciplinary Research and Biomedical Innovation, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico., Alarcón-Paredes A; Laboratory of Multidisciplinary Research and Biomedical Innovation, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico., Navarro-Zarza JE; Hospital General Dr. Raymundo Abarca Alarcón, Chilpancingo, Guerrero, Mexico., Morales-Martínez C; Hospital General Dr. José G. Parres, Cuernavaca, Morelos, Mexico., Rodríguez-García R; Laboratorio de Clínico, Instituto Mexicano del Seguro Social, Hospital General Regional, Cuernavaca, Morelos, Mexico., Guzmán-Guzmán IP; Laboratory of Multidisciplinary Research and Biomedical Innovation, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico. Electronic address: pao_nkiller@yahoo.com.mx.
Jazyk: English; Spanish; Castilian
Zdroj: Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis [Clin Investig Arterioscler] 2024 May 09. Date of Electronic Publication: 2024 May 09.
DOI: 10.1016/j.arteri.2024.04.002
Abstrakt: Aim: The soluble scavenger receptor differentiation antigen 163 (sCD163), a monocyte/macrophage activation marker, is related to cardiovascular mortality in the general population. This study aimed to evaluate their relationship between serum levels of sCD163 with cardiovascular risk indicators in rheumatoid arthritis (RA).
Methods: A cross-sectional study was performed on 80 women diagnosed with RA. The cardiovascular risks were determined using the lipid profile, metabolic syndrome, and QRISK3 calculator. For the assessment of RA activity, we evaluated the DAS28 with erythrocyte sedimentation rate (DAS28-ESR). The serum levels of sCD163 were determined by the ELISA method. Logistic regression models and receiver operating characteristics (ROC) curve were used to assess the association and predictive value of sCD163 with cardiovascular risk in RA patients.
Results: Levels of sCD163 were significantly higher in RA patients with high sensitivity protein C-reactive to HDL-c ratio (CHR)≥0.121 (p=0.003), total cholesterol/HDL-c ratio>7% (p=0.004), LDL-c/HDL-c ratio>3% (p=0.035), atherogenic index of plasma>0.21 (p=0.004), cardiometabolic index (CMI)≥1.70 (p=0.005), and high DAS28-ESR (p=0.004). In multivariate analysis, levels of sCD163≥1107.3ng/mL were associated with CHR≥0.121 (OR=3.43, p=0.020), CMI≥1.70 (OR=4.25, p=0.005), total cholesterol/HDL-c ratio>7% (OR=6.63, p=0.044), as well as with DAS28-ESR>3.2 (OR=8.10, p=0.008). Moreover, levels of sCD163 predicted CHR≥0.121 (AUC=0.701), cholesterol total/HDL ratio>7% (AUC=0.764), and DAS28-ESR>3.2 (AUC=0.720).
Conclusion: Serum levels of sCD163 could be considered a surrogate of cardiovascular risk and clinical activity in RA.
(Copyright © 2024 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE