Echovirus 11 lineage I and other enteroviruses in hospitalized children with acute respiratory infection in Southern Italy, 2022- 2023.

Autor:	Loconsole D; Department of Interdisciplinary Medicine, Hygiene Section, 'Aldo Moro' University of Bari, Bari, Italy., Centrone F; Hygiene Unit, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy., Sallustio A; Hygiene Unit, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy., Casulli D; Hygiene Unit, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy., Zagaria R; Department of Interdisciplinary Medicine, Hygiene Section, 'Aldo Moro' University of Bari, Bari, Italy., Sacco D; Department of Interdisciplinary Medicine, Hygiene Section, 'Aldo Moro' University of Bari, Bari, Italy., Colella V; Department of Interdisciplinary Medicine, Hygiene Section, 'Aldo Moro' University of Bari, Bari, Italy., Albano N; Department of Health Promotion and Animal Welfare, Apulia Region, Bari, Italy., Caselli D; Infectious Diseases, Children's Hospital Giovanni XXIII, Bari, Italy., Cardinale F; Pediatric and Emergency Department, Pediatric Pulmonology and Immunology section, Giovanni XXIII Pediatric Hospital, 'Aldo Moro' University of Bari, Bari, Italy., Giordano P; Department of Interdisciplinary Medicine, Pediatric Section, 'Aldo Moro' University of Bari, Bari, Italy., Lofù I; Pediatric Unit, Maternal and Child Health Department, 'S. Giacomo' Hospital, ASL BA, Bari, Italy., Laforgia N; Section of Neonatology and Neonatal Intensive Care Unit, Department of Interdisciplinary Medicine, 'Aldo Moro' University of Bari, Bari, Italy., Chironna M; Department of Interdisciplinary Medicine, Hygiene Section, 'Aldo Moro' University of Bari, Bari, Italy. Electronic address: maria.chironna@uniba.it.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Sep; Vol. 146, pp. 107091. Date of Electronic Publication: 2024 May 08.
DOI:	10.1016/j.ijid.2024.107091
Abstrakt:	Objectives: A new variant of echovirus 11 (E11) infection is a major health concern in neonates. Here, we describe the clinical and virological characteristics of enterovirus (EV) infections in children hospitalized with acute respiratory infection in Southern Italy. Methods: Between July 2022 and August 2023, 173 EV infections were identified. Demographic and clinical characteristics, comorbidities, and coinfections were analyzed. Genotypes were identified by sequencing of VP1. Whole-genome sequencing of five E11 strains was performed. Results: Case numbers peaked in July 2022, November-December 2022, and June-July 2023. Coxsackievirus A2 was identified in 36.7%, coxsackievirus B5 in 13.8%, echovirus E11 in 9.2%, and EV-D68 in 6.4% of cases. No child had critical symptoms or a severe infection. The only neonate infected by E11 recovered fully after 5 days in hospital. Phylogenetic analysis revealed that four E11 strains were closely related to divergent lineage I E11 strains identified in France and Italy. Conclusions: The new variant of E11 was identified in children in Southern Italy. Although the cases were mild, the data suggest that transmission routes and host factors are likely to be main drivers for the development of potentially severe diseases. Systematic epidemiological/molecular surveillance will help us better understand the clinical impact of EV infections and develop preventive strategies. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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