Effects of Euphorbia characias subsp. characias flower extracts on nociceptive pain and acute inflammatory models in mice.

Autor: Di Petrillo A; Department of Medical Science and Public Health, Gastroenterology Unit, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Cagliari, Italy. Electronic address: amalia.dip@unica.it., Pintus F; Department of Life and Environmental Sciences, University of Cagliari, SS 554-Bivio per Sestu, Monserrato, 09042, Cagliari, Italy. Electronic address: fpintus@unica.it., Floris S; Department of Life and Environmental Sciences, University of Cagliari, SS 554-Bivio per Sestu, Monserrato, 09042, Cagliari, Italy. Electronic address: s.floris@unica.it., Tuberoso CIG; Department of Life and Environmental Sciences, University of Cagliari, SS 554-Bivio per Sestu, Monserrato, 09042, Cagliari, Italy. Electronic address: tuberoso@unica.it., de Almeida ABABS; Laboratório de Farmacologia da Dor e da Inflamação, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil., Giorno TBS; Laboratório de Farmacologia da Dor e da Inflamação, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil., Fernandes PD; School of Pharmacy and Pharmaceutical Sciences, Panoz Institute and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Boylan F; School of Pharmacy and Pharmaceutical Sciences, Panoz Institute and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: fabio.boylan@tcd.ie.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Jul; Vol. 176, pp. 106002. Date of Electronic Publication: 2024 May 08.
DOI: 10.1016/j.fitote.2024.106002
Abstrakt: Pain and inflammation are major health issues worldwide, leading to negative consequences. Despite several drugs being available to manage these conditions, their effectiveness can be limited by cost, adverse reactions, and potential tolerance and dependence with long-term use. Euphorbia characias traditionally used in folk medicine for its diverse biological activities - including antiproliferative, antimicrobial, and anti-inflammatory effects - has not been extensively studied in vivo for its analgesic and anti-inflammatory properties. In this study, the antinociceptive and anti-inflammatory properties of the water and ethanolic extracts of E. characias flowers (ECAEFl and ECEEFl) were evaluated using various models. Both extracts significantly reduced paw licking time in a formalin-induced paw licking model, with ECAEFl specifically targeting and ECEEFl affecting both the neurogenic and inflammatory phases. Additionally, in the carrageenan-induced cell migration model, both extracts showed a significant decrease in leukocyte migration, protein extravasation and nitric oxide levels, further demostrating their anti-inflammatory activity. High-Resolution HPLC-ESI-QTOF-MS-MS and HPLC-PDA analysis characterized the chemical composition of the extracts, identifying a significant presence of phenolic compounds, particularly quercetin and its derivatives, which likely contribute to the observed biological activities. These findings highlight the potential of E. characias extracts as natural sources of compounds with antinociceptive and anti-inflammatory properties. Further investigations are needed to elucidate the underlying mechanisms and explore their therapeutic potential in pain and inflammation-related disorders.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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