Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?

Autor: Ritson M; Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK., Wheeler-Jones CPD; Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK., Stolp HB; Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK. Electronic address: hstolp@rvc.ac.uk.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2024 Jun 15; Vol. 391, pp. 578363. Date of Electronic Publication: 2024 May 03.
DOI: 10.1016/j.jneuroim.2024.578363
Abstrakt: Neurological diseases with a neurodegenerative component have been associated with alterations in the cerebrovasculature. At the anatomical level, these are centred around changes in cerebral blood flow and vessel organisation. At the molecular level, there is extensive expression of cellular adhesion molecules and increased release of pro-inflammatory mediators. Together, these has been found to negatively impact blood-brain barrier integrity. Systemic inflammation has been found to accelerate and exacerbate endothelial dysfunction, neuroinflammation and degeneration. Here, we review the role of cerebrovasculature dysfunction in neurodegenerative disease and discuss the potential contribution of intermittent pro-inflammatory systemic disease in causing endothelial pathology, highlighting a possible mechanism that may allow broad-spectrum therapeutic targeting in the future.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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