Dengue virus serotypes and related factors in children with dengue hemorrhagic fever in Southern Vietnam.

Autor:	Quang Tran K; Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Vietnam., Hung Pham V; Laboratory of Nam Khoa Biotek Company, Vietnam Research and Development Institute of Clinical Microbiology, Ho Chi Minh City 700000, Vietnam., Thi Ngoc Tran T; Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Vietnam., Thao Mai C; Department of Infectious Diseases Prevention, Center for Disease Control of Kien Giang Province, Rach Gia City 91100, Vietnam., Kieu Anh Pham T; Department of Physiology, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Vietnam., Hoang Ngo T; Department of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Vietnam., Bui Thai Nguyen H; Department of Infectious Diseases, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Vietnam., Manh Nguyen C; Department of Pediatrics, Military Hospital 103, Vietnam Military Medical University, Hanoi 100000, Vietnam., Van Duong H; Can Tho Children's Hospital, Can Tho City 90000, Vietnam., Minh Nguyen P; Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Vietnam.
Jazyk:	angličtina
Zdroj:	Journal of infection in developing countries [J Infect Dev Ctries] 2024 Apr 30; Vol. 18 (4), pp. 495-500. Date of Electronic Publication: 2024 Apr 30.
DOI:	10.3855/jidc.18900
Abstrakt:	Introduction: After the Coronavirus Disease 2019 pandemic, a high number of cases and severe dengue in children were reported in some provinces in the south of Vietnam. This study aimed to determine the distribution of dengue virus serotypes and their correlation with demographic factors, disease severity, clinical manifestations, and laboratory findings. Methodology: This study employed a cross-sectional design. Ninety-six dengue-infected children admitted to Can Tho Children's Hospital between October 2022 and March 2023 were included. Confirmation of dengue infection was achieved through the real-time polymerase chain reaction (RT-PCR). Results: Among the identified serotypes, DENV-2 accounted for the highest proportion (71.87%), followed by DENV-1 (23.96%), and DENV-4 (4.17%). DENV-3 was not detected. No significant demographic, disease severity, or laboratory differences were observed among the identified dengue serotypes. However, DENV-2 was associated with a higher occurrence of mucous membrane hemorrhages and gastrointestinal bleeding compared to other serotypes. Conclusions: Although DENV-2 was the most prevalent serotype responsible for dengue in children in southern Vietnam, it did not lead to more severe cases compared to other serotypes. This finding is crucial for evaluating the illness's prognosis. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2024 Khai Quang Tran, Van Hung Pham, Trieu Thi Ngoc Tran, Chi Thao Mai, Tho Kieu Anh Pham, Toan Hoang Ngo, Huy Bui Thai Nguyen, Cuong Manh Nguyen; Hieu Van Duong; Phuong Minh Nguyen.)
Databáze:	MEDLINE
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