Harnessing polyelectrolyte complexes for precision cancer targeting: a comprehensive review.

Autor: Prajapati BG; Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, Gujarat, 384012, India. bhupen27@gmail.com., Sharma JB; MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India., Sharma S; Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, India., Trivedi ND; AR College of Pharmacy & GH Institute of Pharmacy, VV Nagar, Anand, Gujarat, 388120, India., Gaur M; Rajasthan Pharmacy College, Rajasthan University of Health Sciences, Jaipur, Rajasthan, 302026, India., Kapoor DU; Dr. Dayaram Patel Pharmacy College, Bardoli, Gujarat, 394601, India. dev7200@gmail.com.
Jazyk: angličtina
Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2024 May 10; Vol. 41 (6), pp. 145. Date of Electronic Publication: 2024 May 10.
DOI: 10.1007/s12032-024-02354-0
Abstrakt: Polyelectrolytes represent a unique class of polymers abundant in ionizable functional groups. In a solution, ionized polyelectrolytes can intricately bond with oppositely charged counterparts, giving rise to a fascinating phenomenon known as a polyelectrolyte complex. These complexes arise from the interaction between oppositely charged entities, such as polymers, drugs, and combinations thereof. The polyelectrolyte complexes are highly appealing in cancer management, play an indispensable role in chemotherapy, crafting biodegradable, biocompatible 3D membranes, microcapsules, and nano-sized formulations. These versatile complexes are pivotal in designing controlled and targeted release drug delivery systems. The present review emphasizes on classification of polyelectrolyte complex along with their formation mechanisms. This review comprehensively explores the applications of polyelectrolyte complex, highlighting their efficacy in targeted drug delivery strategies for combating different forms of cancer. The innovative use of polyelectrolyte complex presents a potential breakthrough in cancer therapeutics, demonstrating their role in enhancing treatment precision and effectiveness.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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