Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke.

Autor:	Salim H; Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.; Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Musmar B; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA., Adeeb N; Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, LA, USA., Yedavalli V; Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA., Lakhani D; Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA., Grewal SS; Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada., El Naamani K; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA., Henninger N; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Sundararajan SH; Department of Endovascular Neurosurgery and Neuroradiology NJMS, Newark, NJ, USA., Kühn AL; Division of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA., Khalife J; Cooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA., Ghozy S; Departments of Neurological Surgery & Radiology, Mayo Clinic, Rochester, MN, USA., Scarcia L; Department of Neuroradiology, Henri Mondor Hospital, Creteil, France., Tan BY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Division of Neurology, Department of Medicine, National University Hospital, Singapore., Regenhardt RW; Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Heit JJ; Department of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA., Cancelliere NM; Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada., Bernstock JD; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA., Rouchaud A; Neuroradiology Department, Dupuytren, University Hospital of Limoges, Université de Limoges, Limoges, France., Fiehler J; Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sheth S; Department of Neurology, UTHealth McGovern Medical School, Houston, TX, USA., Puri AS; Division of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA., Dyzmann C; Neuroradiology Department, Sana Kliniken, Lübeck GmbH, Lübeck, Germany., Colasurdo M; Department of Interventional Radiology, Oregon Health and Science University, Portland, OR, USA., Barreau X; Interventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France., Renieri L; Interventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy., Filipe JP; Department of Diagnostic and Interventional Neuroradiology, Centro Hospitalar Universitário do Porto, Porto, Portugal., Harker P; Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA., Radu RA; Department of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, France., Abdalkader M; Departments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA., Klein P; Departments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA., Marotta TR; Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada., Spears J; Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada., Ota T; Department of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan., Mowla A; Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California (USC), Suite, Los Angeles, CA, USA., Jabbour P; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA., Biswas A; Department of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, USA., Clarençon F; Department of Neuroradiology, Pitié-Salpêtrière Hospital, GRC BioFast, Sorbonne University. Paris VI, France., Siegler JE; Cooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA., Nguyen TN; Departments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA., Varela R; Department of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal., Baker A; Department of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA., Essibayi MA; Department of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA., Altschul D; Department of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA., Gonzalez NR; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Möhlenbruch MA; Sektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany., Costalat V; Department of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, France., Gory B; Department of Interventional Neuroradiology, Nancy University Hospital, Nancy, France.; INSERM U1254, IADI, Université de Lorraine, Vandoeuvre-les-Nancy, France., Stracke CP; Department of Radiology, Interventional Neuroradiology Section, University Medical Center Münster, Germany., Aziz-Sultan MA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA., Hecker C; Departments of Neurology & Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University Salzburg, Austria., Shaikh H; Cooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA., Liebeskind DS; UCLA Stroke Center and Department of Neurology Department, UCLA, Los Angeles, CA, USA., Pedicelli A; UOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Italy., Alexandre AM; UOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Italy., Tancredi I; Department of Neurology, Hôpital Civil Marie Curie, Charleroi, Belgium., Faizy TD; Department of Radiology, Neuroendovascular Program, University Medical Center Münster, Germany., Kalsoum E; Department of Neuroradiology, Henri Mondor Hospital, Creteil, France., Lubicz B; Department of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium., Patel AB; Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Pereira VM; Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada., Guenego A; Department of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium., Dmytriw AA; Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Neurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael Hospital, University of Toronto, Toronto, ON, Canada.
Jazyk:	angličtina
Zdroj:	European stroke journal [Eur Stroke J] 2024 May 10, pp. 23969873241249295. Date of Electronic Publication: 2024 May 10.
DOI:	10.1177/23969873241249295
Abstrakt:	Background: Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occlusions (DMVO) are not well understood. Methods: This retrospective analysis involved 1282 acute ischemic stroke (AIS) patients who underwent MT in 37 centers across North America, Asia, and Europe from September 2017 to July 2023. Data on demographics, clinical presentation, treatment specifics, and outcomes were collected. The primary outcomes were functional outcomes at 90 days post-MT, measured by modified Rankin Scale (mRS) scores. Secondary outcomes included reperfusion rates, mortality, and hemorrhagic complications. Results: Of the patients, 223 (34%) were on anticoagulation therapy. Anticoagulated patients were older (median age 78 vs 74 years; p  < 0.001) and had a higher prevalence of atrial fibrillation (77% vs 26%; p  < 0.001). Their baseline National Institutes of Health Stroke Scale (NIHSS) scores were also higher (median 12 vs 9; p  = 0.002). Before propensity score matching (PSM), anticoagulated patients had similar rates of favorable 90-day outcomes (mRS 0-1: 30% vs 37%, p  = 0.1; mRS 0-2: 47% vs 50%, p  = 0.41) but higher mortality (26% vs 17%, p  = 0.008). After PSM, there were no significant differences in outcomes between the two groups. Conclusion: Anticoagulated patients undergoing MT for AIS due to DMVO did not show significant differences in 90-day mRS outcomes, reperfusion, or hemorrhage compared to non-anticoagulated patients after adjustment for covariates. Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr. Regenhardt serves on a DSMB for a trial sponsored by Rapid Medical, serves as site PI for studies sponsored by Penumbra and Microvention, and receives stroke research grant funding from the National Institutes of Health, Society of Vascular and Interventional Neurology, and Heitman Stroke Foundation.Dr. Guenego reports consultancy for Rapid Medical and Phenox, not directly related to the present work.Dr. Clarençon reports conflicts of interest with Medtronic, Balt Extrusion (consultant), ClinSearch (core lab), Penumbra, Stryker (payment for reading) and Artedrone (Board); all not directly related to the present work.Dr. Henninger received support from W81XWH-19-PRARP-RPA form the CDMRP/DoD, NS131756 and U24NS113844 from the NINDS, and NR020231 from the NINR and received compensation from Myrobalan, Inc. and General Dynamics during the conduct of this study unrelated to this work.Dr. Liebeskind is consultant as Imaging Core Lab to Cerenovus, Genentech, Medtronic, Stryker, Rapid Medical.Dr. Yeo reports Advisory work for AstraZeneca, Substantial support from NMRC Singapore and is a medical advisor for See-mode, Cortiro and Sunbird Bio, with equity in Ceroflo. All unrelated to the present work.Dr. Griessenauer reports a proctoring agreement with Medtronic and research funding by Penumbra.Dr. Marnat reports conflicts of interest with Microvention Europe, Stryker Neurovascular, Balt (consulting), Medtronic, Johnson & Johnson and Phenox (paid lectures), all not directly related to the present work.Dr. Puri is a consultant for Medtronic Neurovascular, Stryker NeurovascularBalt, Q’Apel Medical, Cerenovus, Microvention, Imperative Care, Agile, Merit, CereVasc and Arsenal Medical, he received research grants from NIH, Microvention, Cerenovus, Medtronic Neurovascular and Stryker Neurovascular, and holds stocks in InNeuroCo, Agile, Perfuze, Galaxy and NTI.Dr. Tjoumakaris is a consultant for Medtronic and Microvention (funds paid to institution, not personally).Dr. Jabbour is a consultant for Medtronic, Microvention and Cerus.
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