Genetically engineered bacteriophages as novel nanomaterials: applications beyond antimicrobial agents.
| Autor: | Kim SM; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea., Heo HR; Department of Chemical and Biochemical Engineering, Dongguk University, Seoul, Republic of Korea., Kim CS; Department of Chemical and Biochemical Engineering, Dongguk University, Seoul, Republic of Korea., Shin HH; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2024 Apr 25; Vol. 12, pp. 1319830. Date of Electronic Publication: 2024 Apr 25 (Print Publication: 2024). |
| DOI: | 10.3389/fbioe.2024.1319830 |
| Abstrakt: | Bacteriophages, also known as phages, are viruses that replicate in bacteria and archaea. Phages were initially discovered as antimicrobial agents, and they have been used as therapeutic agents for bacterial infection in a process known as "phage therapy." Recently, phages have been investigated as functional nanomaterials in a variety of areas, as they can function not only as therapeutic agents but also as biosensors and tissue regenerative materials. Phages are nontoxic to humans, and they possess self-assembled nanostructures and functional properties. Additionally, phages can be easily genetically modified to display specific peptides or to screen for functional peptides via phage display. Here, we demonstrated the application of phage nanomaterials in the context of tissue engineering, sensing, and probing. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Kim, Heo, Kim and Shin.) |
| Databáze: | MEDLINE |
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