Pernicious Anemia Unveiled: Unusual Hemolytic Complications and Clinical Implications.

Autor:	Trivedi M; Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Areti A; Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Venishetty N; Orthopedic Surgery, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Parikh A; Internal Medicine, Huntington Hospital, Pasadena, USA.; Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Didia C; Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Apr 09; Vol. 16 (4), pp. e57901. Date of Electronic Publication: 2024 Apr 09 (Print Publication: 2024).
DOI:	10.7759/cureus.57901
Abstrakt:	Pernicious anemia (PA) is an autoimmune condition resulting in impaired vitamin B12 absorption that commonly presents with gastritis and neurological symptoms. In rare cases, associated vitamin B12 deficiency can contribute to significant red blood cell lysis, and patients can present with PA-induced pseudo-thrombotic microangiopathy (TMA) hemolytic anemia. This case describes a 59-year-old male presenting with a two-week history of gastrointestinal pain with bleeding who had anemia and hemodynamic instability on initial evaluation. After the endoscopy/colonoscopy did not reveal any active sources of bleeding and packed red blood cells failed to stabilize the patient, it was found that he had low serum B12 with anti-intrinsic factor and anti-parietal cell antibodies. A coordinated clinical approach, including parenteral cyanocobalamin and daily oral folic acid supplementation, stabilized the patient, highlighting the importance of distinguishing PA-induced pseudo-TMA from true TMA hemolytic anemia. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Trivedi et al.)
Databáze:	MEDLINE
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