Demographic fluctuations in bloodstream Staphylococcus aureus lineages configure the mobile gene pool and antimicrobial resistance.

Autor: Souza SSR; Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, NY USA., Smith JT; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH USA.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA USA., Marcovici MM; Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, NY USA., Eckhardt EM; Dartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH USA., Hansel NB; Dartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH USA., Martin IW; Dartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH USA., Andam CP; Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, NY USA.
Jazyk: angličtina
Zdroj: Npj antimicrobials and resistance [NPJ Antimicrob Resist] 2024; Vol. 2 (1), pp. 14. Date of Electronic Publication: 2024 May 07.
DOI: 10.1038/s44259-024-00032-9
Abstrakt: Staphylococcus aureus in the bloodstream causes high morbidity and mortality, exacerbated by the spread of multidrug-resistant and methicillin-resistant S. aureus (MRSA). We aimed to characterize the circulating lineages of S. aureus from bloodstream infections and the contribution of individual lineages to resistance over time. Here, we generated 852 high-quality short-read draft genome sequences of S. aureus isolates from patient blood cultures in a single hospital from 2010 to 2022. A total of 80 previously recognized sequence types (ST) and five major clonal complexes are present in the population. Two frequently detected lineages, ST5 and ST8 exhibited fluctuating demographic structures throughout their histories. The rise and fall in their population growth coincided with the acquisition of antimicrobial resistance, mobile genetic elements, and superantigen genes, thus shaping the accessory genome structure across the entire population. These results reflect undetected selective events and changing ecology of multidrug-resistant S. aureus in the bloodstream.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© The Author(s) 2024.)
Databáze: MEDLINE
Externí odkaz: