Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus.

Autor: Klyosova EY; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. ecless@yandex.ru., Azarova YE; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia., Ilyina EA; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia., Goryainova NV; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia., Polonikov AV; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Mar; Vol. 176 (5), pp. 599-602. Date of Electronic Publication: 2024 May 09.
DOI: 10.1007/s10517-024-06075-2
Abstrakt: We studied the relationship between the HSPA5 gene polymorphisms and the risk of type 2 diabetes mellitus. Genotyping of three SNPs of the HSPA5 gene was performed in 1579 patients with type 2 diabetes mellitus and 1650 healthy individuals. It was found that the genotypes rs55736103-T/T, rs12009-G/G, and rs391957-T/C-T/T are associated with increased risk of type 2 diabetes in females. A rare haplotype, rs55736103C-rs12009A-rs391957T HSPA5, associated with a reduced risk of type 2 diabetes in females was found. Associations between polymorphisms of the HSPA5 gene encoding heat shock protein and the risk of type 2 diabetes mellitus were established for the first time.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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