Efficacy of live and inactivated recombinant Newcastle disease virus vaccines expressing clade 2.3.4.4b H5 hemagglutinin against H5N1 highly pathogenic avian influenza in SPF chickens, Broilers, and domestic ducks.

Autor: Kim DH; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, South Korea; KHAV Co., Ltd., 1 Hwayang-dong, Gwangjin-gu, Seoul, Korea., Lee SH; KHAV Co., Ltd., 1 Hwayang-dong, Gwangjin-gu, Seoul, Korea., Kim J; KHAV Co., Ltd., 1 Hwayang-dong, Gwangjin-gu, Seoul, Korea., Lee J; Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, U.S. Department of Agriculture-Agricultural Research Service, 934 College Station Road, Athens, GA 30605, USA., Jeong JH; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, South Korea; KHAV Co., Ltd., 1 Hwayang-dong, Gwangjin-gu, Seoul, Korea., Kim JY; KHAV Co., Ltd., 1 Hwayang-dong, Gwangjin-gu, Seoul, Korea., Song SU; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, South Korea., Lee H; KHAV Co., Ltd., 1 Hwayang-dong, Gwangjin-gu, Seoul, Korea., Cho AY; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, South Korea., Hyeon JY; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, South Korea., Youk S; Department of Microbiology, College of Medicine, Chungbuk National University, Cheongju, South Korea. Electronic address: sungsu.youk@chungbuk.ac.kr., Song CS; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, South Korea; KHAV Co., Ltd., 1 Hwayang-dong, Gwangjin-gu, Seoul, Korea. Electronic address: songcs@konkuk.ac.kr.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Jul 11; Vol. 42 (18), pp. 3756-3767. Date of Electronic Publication: 2024 May 09.
DOI: 10.1016/j.vaccine.2024.04.088
Abstrakt: A Newcastle disease virus (NDV)-vectored vaccine expressing clade 2.3.4.4b H5 Hemagglutinin was developed and assessed for efficacy against H5N1 highly pathogenic avian influenza (HPAI) in specific pathogen-free (SPF) chickens, broilers, and domestic ducks. In SPF chickens, the live recombinant NDV-vectored vaccine, rK148/22-H5, achieved complete survival against HPAI and NDV challenges and significantly reduced viral shedding. Notably, the live rK148/22-H5 vaccine conferred good clinical protection in broilers despite the presence of maternally derived antibodies. Good clinical protection was observed in domestic ducks, with decreased viral shedding. It demonstrated complete survival and reduced cloacal viral shedding when used as an inactivated vaccine from SPF chickens. The rK148/22-H5 vaccine is potentially a viable and supportive option for biosecurity measure, effectively protecting in chickens against the deadly clade 2.3.4.4b H5 HPAI and NDV infections. Furthermore, it aligns with the strategy of Differentiating Infected from Vaccinated Animals (DIVA).
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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