Pan-Enteric Crohn's Capsule [Eliakim] Score Reliability and Responsiveness to Change in Active Crohn's Disease.

Autor:	Ukashi O; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.; Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel., Lahat A; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.; Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel., Ungar B; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.; Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel., Levy H; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.; Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel., Finkel O; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.; Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel., Eidler P; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel., Ben-Horin S; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.; Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel., Eliakim R; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.; Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel., Kopylov U; Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.; Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel.
Jazyk:	angličtina
Zdroj:	Journal of Crohn's & colitis [J Crohns Colitis] 2024 Oct 15; Vol. 18 (10), pp. 1622-1630.
DOI:	10.1093/ecco-jcc/jjae068
Abstrakt:	Background and Aims: Pan-enteric capsule endoscopy (PillCam Crohn's capsule [PCC]) is a useful tool in diagnosing and monitoring Crohn's disease [CD]. Eliakim score [ES] reliability and its strong correlation to Lewis score [LS] and to inflammatory biomarkers have been previously demonstrated using PCC in quiescent CD. We aimed to examine ES performance in active CD and its responsiveness to clinical/biochemical change over time. Methods: Patients with CD who have started biologics were included, and were prospectively followed based on clinical visits, biomarkers, and PCC at baseline, after 14 and 52 weeks. Crohn's disease activity index [CDAI], C-reactive protein [CRP], and faecal calprotectin [FC] levels were determined, and LS and ES were calculated [independently reviewed by two experienced readers]. Inter-class classification [ICC], Spearman's baseline correlation, and repeated-measures correlation [RMC] analyses were performed. Results: Seventy-four patients were included (age: 30.5 [range 23.3-45.0] years old, male 50%). In total, 142 PCCs were read [baseline, 62; week 14, 58; week 52, 22]. Inter-rater agreement was high for both LS and ES (ICC: 0.872 [p < 0.001] and 0.925 [<0.001], respectively). Baseline correlations between FC&ES [r = 0.509 [p < 0.001]) and FC&LS (r = 0.467 [p < 0.001]) were comparable [p = 0.56]. RMCs between the inflammatory biomarkers and ES were higher than between the former and LS (Reader 1: CRP r = 0.306 vs r = 0.138 [p = 0.057], FC r = 0.479 vs r = 0.297 [p = 0.034]; Reader 2 CRP r = 0.376 vs r = 0.204 [p = 0.035], FC r = 0.549 vs r = 0.412 [p = 0.075]). Moreover, ES was better correlated to CDAI than LS [p = 0.036]. Conclusions: ES is a reliable scoring system in assessing pan-enteric mucosal inflammation in active CD, and might have a better responsiveness to clinical/biochemical change over time compared to LS. (© The Author(s) 2024. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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