Influence of Blood Pressure Reduction on Pulse Wave Velocity in Primary Hypertension: A Meta-Analysis and Comparison With an Acute Modulation of Transmural Pressure.

Autor:	McNally RJ; King's College London, Department of Vascular Risk and Surgery, British Heart Foundation Centre, United Kingdom (R.J.M., C.N.F., M.C., B.F., P.C., L.F.)., Boguslavskyi A; Cardiac Outpatient Department, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom (A.B.)., Malek R; King's College London, School of Life Course and Population Sciences, United Kingdom (R.M., A.D.)., Floyd CN; King's College London, Department of Vascular Risk and Surgery, British Heart Foundation Centre, United Kingdom (R.J.M., C.N.F., M.C., B.F., P.C., L.F.)., Cecelja M; King's College London, Department of Vascular Risk and Surgery, British Heart Foundation Centre, United Kingdom (R.J.M., C.N.F., M.C., B.F., P.C., L.F.)., Douiri A; King's College London, School of Life Course and Population Sciences, United Kingdom (R.M., A.D.)., Bruno RM; Université Paris Cité, INSERM U970 Team 7, Paris Cardiovascular Research Centre - PARCC, France (R.-M.B.)., Farukh B; King's College London, Department of Vascular Risk and Surgery, British Heart Foundation Centre, United Kingdom (R.J.M., C.N.F., M.C., B.F., P.C., L.F.)., Chowienczyk P; King's College London, Department of Vascular Risk and Surgery, British Heart Foundation Centre, United Kingdom (R.J.M., C.N.F., M.C., B.F., P.C., L.F.)., Faconti L; King's College London, Department of Vascular Risk and Surgery, British Heart Foundation Centre, United Kingdom (R.J.M., C.N.F., M.C., B.F., P.C., L.F.).
Jazyk:	angličtina
Zdroj:	Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Jul; Vol. 81 (7), pp. 1619-1627. Date of Electronic Publication: 2024 May 09.
DOI:	10.1161/HYPERTENSIONAHA.123.22436
Abstrakt:	Background: Increased arterial stiffness and pulse wave velocity (PWV) of the aorta and large arteries impose adverse hemodynamic effects on the heart and other organs. Antihypertensive treatment reduces PWV, but it is unknown whether this results from an unloading of stiffer elements in the arterial wall or is due to an alternate functional or structural change that might differ according to class of antihypertensive drug. Methods: We performed a systematic review and meta-analysis of the effects of different antihypertensive drug classes and duration of treatment on PWV with and without adjustment for change in mean arterial blood pressure (BP; study 1) and compared this to the change in PWV after an acute change in transmural pressure, simulating an acute change in BP (study 2). Results: A total of 83 studies involving 6200 subjects were identified. For all drug classes combined, the reduction of PWV was 0.65 (95% CI, 0.46-0.83) m/s per 10 mm Hg reduction in mean arterial BP, a change similar to that induced by an acute change in transmural pressure in a group of hypertensive subjects. When adjusted for change in mean arterial BP, the reduction in PWV after treatment with beta-blockers or diuretics was less than that after treatment with angiotensin-converting enzyme inhibitors/angiotensin receptor antagonists or calcium channel antagonists. Conclusions: Reduction in PWV after antihypertensive treatment is largely explained by the reduction in BP, but there are some BP-independent effects. These might increase over time and contribute to better outcomes over the long term, but this remains to be demonstrated in long-term clinical trials. Competing Interests: Disclosures None.
Databáze:	MEDLINE
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