The impact of nodule size on malignancy risk in indeterminate thyroid nodules.

Autor:	Alqahtani SM; Department of Surgery, College of Medicine, Majmaah University, Al-Majmaah, Saudi Arabia., Albalawi HI; Department of Surgery, King Fahad Specialist Hospital, Tabuk, Saudi Arabia., Alalawi YS; Department of Surgery, King Salman Armed Forces Hospital Northwestern Region, Tabuk, Saudi Arabia., AlFattani AA; Department of Biostatistics, Epidemiology, and Scientific Computing, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia., Al-Sobhi SS; Department of Surgery, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Gland surgery [Gland Surg] 2024 Apr 29; Vol. 13 (4), pp. 470-479. Date of Electronic Publication: 2024 Apr 18.
DOI:	10.21037/gs-24-12
Abstrakt:	Background: The association between malignancy risk and nodule size in indeterminate thyroid nodules (ITNs) remains controversial. Thus, we aimed to explore the impact of nodule size as a predictor of cancer in patients with ITNs. Methods: This cross-sectional study assessed 113 patients who underwent surgical intervention for ITNs, comparing two groups based on nodule size (≥4 or <4 cm). The correlation between nodule size and malignancy risk was examined. Other variables of interest included demographics, thyroid-stimulating hormone (TSH) levels, type of surgery, and ultrasound features. Results: Of the 113 patients, 88.5% were aged <55 years, 76.1% were women, and 65.5% had nodules <4 cm. Mean nodule size was 3.4±2.3 cm. There was no significant correlation between malignancy risk and nodule size (P=0.55). An association was observed between <4 cm nodules and elevated TSH levels (P=0.03) and between ≥4 cm nodules and the presence of hypervascularity (P=0.04). Nodules <4 cm were more likely to have extrathyroidal extension, lymphovascular invasion, and positive margins than those ≥4 cm; however, this was not significant. Conclusions: Our findings showed no association between nodule size and malignancy risk, suggesting that size alone is not a predictor of cancer development. Further prospective studies are required to confirm these results. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://gs.amegroups.com/article/view/10.21037/gs-24-12/coif). The authors have no conflicts of interest to declare. (2024 Gland Surgery. All rights reserved.)
Databáze:	MEDLINE
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