| Autor: |
Udom GJ; Department of Pharmacology and Toxicology, School of Pharmacy, Kampala International University, Kampala, Uganda.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Federal University Oye-Ekiti, Oye-Ekiti, Nigeria., Obilor OF; Public Health, ManProject Foundation, Port-Harrcourt, Nigeria., Aziakpono OM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Federal University Oye-Ekiti, Oye-Ekiti, Nigeria.; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Akwa, Nigeria., Aturamu A; Department of Human Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria., Ogbonnaya M; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Akwa, Nigeria., Umana IK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University, Elele, Nigeria., Udom NG; Department of Public Health, Faculty of Science and Technology, Cavendish University, Kampala, Uganda., Yemitan OK; Department of Pharmacology, Therapeutics and Toxicology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria. |
| Abstrakt: |
PAHs are pervasive pollutants known to bioaccumulate in environmental matrices, plants, and humans. Dr. Iguedo Goko Cleanser® is a polyherbal drug with unsubstantiated claims to treat various diseases in sub-Saharan Africa. PAHs were measured following EPA-16 PAHs guidelines using Gas Chromatography (Agilent-6890N, USA). The drug's exposure-associated public health concerns was determined using suitable mathematical paradigms. PAHs present were acenaphthene (2.74 × 10 -2 ), pyrene (2.7598 × 10 -2 ), and chrysene (5.1277 × 10 -2 ) ppm. Dietary intake of chrysene, acenaphthene and pyrene for adults, and children ranged from 2.466-4.615 × 10 -3 and 1.215-2.308 × 10 -3 ppm/mg/kg, respectively. B[α]Peq, EDB[α]Peq, and incremental lifetime cancer risk were determined to be 5.6777 × 10 -4 , 5.109912 × 10 -5 and 5.3289 × 10 -12 , respectively. Our results suggest a high risk of non-carcinogenic adverse health effects, especially on chronic exposure among adolescents and adults, necessitating caution and/or avoidance of its chronic use. Therefore, policy formulation and implementation as regards the safety of plant-based remedies and allied products before their distribution among end-users must be ensured. |
