Role of Bilastine in Allergic Rhinitis: A Narrative Review.

Autor:	Tiwaskar M; Consultant Physician and Diabetologist, Shilpa Medical Research Centre, Mumbai, Maharashtra, India, Corresponding Author., Vora A; Chest Physician, Vora Clinic, Mumbai, Maharashtra, India., Tewary K; Former Professor and Head, Department of Medicine, Sri Krishna Medical College, Muzaffarpur, Bihar, India., Prakash A; Director and Professor, Department of Medicine; Head of Department, Department of Accident and Emergency, Lady Hardinge Medical College, Delhi, India., Tripathi KK; Physician and Nephrologist, Ex-Professor and Head, Department of Medicine; Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India., Jain S; Consultant, ENT Surgeon, Department of ENT, ENT Centre, Indore, Madhya Pradesh, India., Ilambarati; Consultant ENT Surgeon, Department of ENT, Billroth Hospital, Chennai, Tamil Nadu, India., Pandit G; ENT Specialist, Department of ENT, Samarth ENT and Allergy Center, Bengaluru, Karnataka, India., Singh BP; Pulmonologist, Department of Pulmonology, Midland Healthcare and Research Centre, Lucknow, Uttar Pradesh, India.
Jazyk:	angličtina
Zdroj:	The Journal of the Association of Physicians of India [J Assoc Physicians India] 2023 Nov; Vol. 71 (11), pp. 58-61.
DOI:	10.59556/japi.71.0401
Abstrakt:	Allergic rhinitis (AR) is considered a trivial disease and is often self-treated with over-the-counter drugs and home remedies. However, AR is a contributing risk factor for asthma associated with complications, including chronic cough, eosinophilic esophagitis, and otitis media with effusion. In AR, inflammation is primarily mediated by histamines. Guidelines advise using second-generation oral H1 antihistamines as the primary treatment for AR. Second-generation H1 antihistamines strongly prefer the H1 receptor, limiting their ability to enter the central nervous system. Thus, they have minimal adverse effects. Among these H1 antihistamines, bilastine is highly specific for H1 receptors with a slight affinity for other receptors. It has a rapid and prolonged action, which reduces the need for frequent dosing and has better compliance. In the long term, bilastine is well-tolerated with minimal adverse effects. It is not associated with drug interactions, so dosage adjustment is unnecessary. Bilastine does not penetrate the brain and is nonsedating at 80 mg once daily. The low possibility of drug-drug interactions and pharmacokinetics of bilastine makes it suitable for elderly patients, even with compromised hepatic and renal function, without dose adjustment. This review comprehensively discusses the guidelines and the role of bilastine in treating AR. How to cite this article : Tiwaskar M, Vora A, Tewary K, et al. Role of Bilastine in Allergic Rhinitis: A Narrative Review. J Assoc Physicians India 2023;71(11):58-61. (© Journal of the Association of Physicians of India 2023.)
Databáze:	MEDLINE
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